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Titolo:
MODELS OF KAPOSI-SARCOMA AND ENDOTHELIAL-CELL ANGIOTUMORIGENICITY IN RODENTS
Autore:
BORGS P; RAMIREZ G; WAY D; BERNAS M; WITTE M; WEINAND M; WITTE C;
Indirizzi:
UNIV ARIZONA,DEPT SURG TUCSON AZ 00000
Titolo Testata:
Lymphology
, volume: 27, anno: 1994, supplemento:, S
pagine: 749 - 752
SICI:
0024-7766(1994)27:<749:MOKAEA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; RAT-LIVER; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
P. Borgs et al., "MODELS OF KAPOSI-SARCOMA AND ENDOTHELIAL-CELL ANGIOTUMORIGENICITY IN RODENTS", Lymphology, 27, 1994, pp. 749-752

Abstract

Cultured cells derived from Kaposi sarcoma (KS) lesions in HIV-seropositive AIDS patients have been injected subcutaneously in nude mice and purported to induce cell growth and transformation, vascular hyperpermeability and angiogenic features analogous to KS. We re-examined this rodent model for KS and extended our studies to include similarly manipulated human non-KS endothelial cells (EC). We also assessed the tumorigenicity of RSE-1, a transformed cell line derived from rat liver sinusoidal EC, in the skin of nude mice and in the liver of Freund's complete adjuvant treated rats. Histologic examination of subcutaneously injected human AIDS-KS and non-KS EC displayed transient focal lesions in various stages of immune cell-mediated rejection. In contrast, RSE-1, in both skin and liver, displayed cell proliferation and early neovascularization. Vascular hyperpermeability (heightened leakage of intravascular T1 824 or Evan's blue dye) was not observed in skin sitesinjected 12hrs previously with AIDS-KS cells. Of note, the growth of RSE-1 in nude mouse skin (5-7 days post-injection) and rat liver (21 days post-injection) mimicked the vascular proliferative and morphogenic features of KS. The insufficiency of current animal models of KS andthe enigma of KS etiology require a renewed search for the factors which promote the growth of human AIDS-KS and transformed EC both in vitro and in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:59:56