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Titolo:
EFFECT OF TUMOR-NECROSIS-FACTOR ON RAT INTESTINAL LYMPH DYNAMICS
Autore:
STUNTZ M; BORGS P; WAY DL; WITTE MH; WITTE CL;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT SURG TORRANCE CA 00000 UNIV ARIZONA,DEPT SURG TUCSON AZ 00000
Titolo Testata:
Lymphology
, volume: 27, anno: 1994, supplemento:, S
pagine: 718 - 720
SICI:
0024-7766(1994)27:<718:EOTORI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
2
Recensione:
Indirizzi per estratti:
Citazione:
M. Stuntz et al., "EFFECT OF TUMOR-NECROSIS-FACTOR ON RAT INTESTINAL LYMPH DYNAMICS", Lymphology, 27, 1994, pp. 718-720

Abstract

The generalized edema that accompanies parenteral interleukin-2 treatment of patients for cancer is thought to be mediated by tumor necrosis factor (TNF). To examine this hypothesis, recombinant human TNF-alpha was administered intravenously to 8 anesthetized male Sprague-Dawleyrats prepared with indwelling intestinal lymphatic and arterial cannulas. After determining lymph and blood parameters the superior mesenteric vein (SMV) was narrowed to raise intestinal microvascular hydrostatic pressure, and lymph flow and protein content further determined. After TNF administration, intestinal lymph flow increased approximately2 fold while the lymph and plasma total protein concentrations were unchanged, effectively doubling lymph protein clearance. Blood hematocrit, mean arterial blood pressure and body temperature were also unchanged after TNF. After SMV constriction, the phenomenon of lymph proteinwashdown (decreased or diluted lymph protein content) was maintained. The similarity of changes in intestinal lymph dynamics after TNF to those previously shown by us with IL-2 support mediation of the edematogenic syndrome through an IL-2/TNF pathway. Moreover, the lack of bulkloss of plasma with either agent (ie. lymph protein washdown effect is retained with raised microvascular hydrostatic pressure) suggests further that increased protein clearance likely relates to recruitment of exchange vessels with greater surface area for leakage rather than compromise in microvascular integrity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:13:17