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Titolo:
ACUTE AND CHRONIC EFFECTS OF ETHANOL ON SPLANCHNIC LYMPH-FLOW AND PROTEIN CLEARANCE IN RATS
Autore:
BORGS P; RAMIREZ G; WAY DL; WITTE MH; WITTE CL;
Indirizzi:
UNIV ARIZONA,DEPT SURG TUCSON AZ 00000
Titolo Testata:
Lymphology
, volume: 27, anno: 1994, supplemento:, S
pagine: 175 - 178
SICI:
0024-7766(1994)27:<175:AACEOE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
P. Borgs et al., "ACUTE AND CHRONIC EFFECTS OF ETHANOL ON SPLANCHNIC LYMPH-FLOW AND PROTEIN CLEARANCE IN RATS", Lymphology, 27, 1994, pp. 175-178

Abstract

The ''intact cell hypothesis'' of alcoholic liver disease (ALD) purports that ingested ethanol (EtOH) primarily targets cell types other than the hepatic parenchyma, such as perisinusoidal accessory cells (fat-storing and myofibroblast), resident or migratory immune cells, and sinusoidal endothelium. Hepatocellular dysfunction then presumably ensues from an altered intrahepatic microenvironment resulting from EtOH-mediated target cell damage. To assess the splanchnic microcirculatory effects of EtOH, the fluid and protein flux in rat hepatic and intestinal lymph was examined after intragastric bolus (acute) and continuous(chronic) EtOH administration. Acutely, in anesthetized rats, the average pre-EtOH hepatic and intestinal lymph flow rates were indistinguishable from the average post-EtOH lymph flow rates measured over 2-4hrs. Chronically, in rats receiving a continuous infusion of a nutritionally complete liquid diet containing 25% total calories as fat and 30-45% as EtOH over 8-16 weeks (Tsukamoto-French model), hepatic lymph flow rates were increased compared to similarly infused controls (EtOH isocalorically substituted with glucose) and chow-fed controls. Intestinal lymph flow rates were unchanged. Plasma and lymph total protein concentrations, venous and arterial blood pressures were unaltered by either acute or chronic EtOH administration. These findings are consistent with early EtOH-mediated non-parenchymal cell alterations in ALD pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:00:48