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Titolo:
DOSIMETRY OF INTRAVENOUSLY ADMINISTERED O-15 LABELED WATER IN MAN - AMODEL-BASED ON EXPERIMENTAL HUMAN DATA FROM 21 SUBJECTS
Autore:
SMITH T; TONG C; LAMMERTSMA AA; BUTLER KR; SCHNORR L; WATSON JDG; RAMSAY S; CLARK JC; JONES T;
Indirizzi:
NORTHWICK PK HOSP & CLIN RES CTR,PHYS MED SECT,WATFORD RD HARROW HA1 3UJ MIDDX ENGLAND HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND
Titolo Testata:
European journal of nuclear medicine
fascicolo: 10, volume: 21, anno: 1994,
pagine: 1126 - 1134
SICI:
0340-6997(1994)21:10<1126:DOIAOL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; CARBON-DIOXIDE; INHALATION;
Keywords:
O-15 LABELED WATER; ARTERIAL INPUT FUNCTION; BIODISTRIBUTION MODEL; RADIATION DOSIMETRY; EFFECTIVE DOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Smith et al., "DOSIMETRY OF INTRAVENOUSLY ADMINISTERED O-15 LABELED WATER IN MAN - AMODEL-BASED ON EXPERIMENTAL HUMAN DATA FROM 21 SUBJECTS", European journal of nuclear medicine, 21(10), 1994, pp. 1126-1134

Abstract

Models based on uniform distribution of tracer in total body water underestimate the absorbed dose from (H2O)-O-15 because of the short half-life (2.04 min) of O-15, which leads to non-uniform distribution of absorbed dose and also complicates the direct measurement of organ retention curves. However, organ absorbed doses can be predicted by the present kinetic model based on the convolution technique. The measured time course of arterial (H2O)-O-15 concentration following intravenousadministration represents the input function to organs. The impulse response of a given organ is its transit time function determined by blood flow and the partition of water between tissue and blood. Values of these two parameters were taken from the literature. Integrals of the arterial input function and organ transit time functions were used to derive integrals of organ retention functions (organ residence times). The latter were used with absorbed dose calculation. software (MIRDOSE-2) to obtain estimates for 24 organs. From the mean values of organ absorbed doses, the effective dose equivalent (EDE) and effective dose (ED) were calculated From measurements on 21 subjects. the average value for both EDE and ED was calculated to be 1.2 mu Sv . MBq(-1) compared with a value of about 0.5 mu Sv . MBq(-1) predicted by uniform water distribution models. Based on the human data, a method of approximating (H2O)-O-15 absorbed dose values from body surface area is described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:28:14