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Titolo:
AMINOTHIOLS LINKED TO QUINOLINE AND ACRIDINE CHROMOPHORES EFFICIENTLYDECREASE 7,8-DIHYDRO-8-OXO-2'-DEOXYGUANOSINE FORMATION IN GAMMA-IRRADIATED DNA
Autore:
LAAYOUN A; COULOMBEAU CE; CONSTANT JF; BERGER M; CADET J; LHOMME J;
Indirizzi:
UNIV GRENOBLE 1,LEDSS,CNRS,URA 332,BP 53 F-38041 GRENOBLE 9 FRANCE UNIV GRENOBLE 1,LEDSS,CNRS,URA 332 F-38041 GRENOBLE 9 FRANCE SESAM,LAN,DEPT RECH FONDAMENTALE MAT CONDENSEE,CEA F-38054 GRENOBLE 9FRANCE
Titolo Testata:
International journal of radiation biology
fascicolo: 3, volume: 66, anno: 1994,
pagine: 259 - 266
SICI:
0955-3002(1994)66:3<259:ALTQAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFYDRYL-CONTAINING COMPOUNDS; STRAND BREAK FORMATION; CO-ION DEPLETION; AQUEOUS-SOLUTION; COUNTERION CONDENSATION; TRANSFORMING DNA; RADICAL PRECURSORS; CHEMICAL REPAIR; APURINIC SITES; OH ADDUCTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A. Laayoun et al., "AMINOTHIOLS LINKED TO QUINOLINE AND ACRIDINE CHROMOPHORES EFFICIENTLYDECREASE 7,8-DIHYDRO-8-OXO-2'-DEOXYGUANOSINE FORMATION IN GAMMA-IRRADIATED DNA", International journal of radiation biology, 66(3), 1994, pp. 259-266

Abstract

In a search for more active radioprotective compounds, we have prepared and examined a series of model molecules in which the radioprotective beta-aminothiol unit (free or derivatized as acetate or phosphorothioate) is tethered to the DNA-binding chromophores quinoline and acridine through links of variable length. The modifying activity of these 'hybrid' molecules was estimated by measuring the formation of 8-oxo-2'-deoxyguanosine (8-oxodGuo) in double-strand DNA upon exposure to gamma-rays in oxygen-free solution in the presence of the drugs. We show that all hybrid molecules protect the guanine moiety from oxidation more efficiently than the parent beta-aminothiol units. The degree of protection is the highest for the molecules in which the thiol is linkedto the strong binding intercalator acridine through a long polyaminochain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:35:46