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Titolo:
LYSOSOMES AND HUMAN LIVER-DISEASE - A BIOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDY OF BETA-HEXOSAMINIDASE
Autore:
ELSAFI ME; HULTBERG B; ISAKSSON A; HAGERSTRAND I; PRYTZ H; STENRAM U;
Indirizzi:
UNIV LUND HOSP,DEPT CLIN CHEM S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN CHEM S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT INTERNAL MED S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PATHOL S-22185 LUND SWEDEN
Titolo Testata:
European journal of clinical chemistry and clinical biochemistry
fascicolo: 9, volume: 32, anno: 1994,
pagine: 669 - 673
SICI:
0939-4974(1994)32:9<669:LAHL-A>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; CHOLESTATIC RATS; SERUM; ENZYMES; LOCALIZATION; IMMUNOASSAY; ISOENZYMES; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Elsafi et al., "LYSOSOMES AND HUMAN LIVER-DISEASE - A BIOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDY OF BETA-HEXOSAMINIDASE", European journal of clinical chemistry and clinical biochemistry, 32(9), 1994, pp. 669-673

Abstract

Liver biopsies from 88 patients with different liver diseases were studied for beta-hexosaminidase activity. Liver specimens with normal light microscopical morphology showed no immunohistochemical reactivity for beta-hexosaminidase. Increased reactions were noted, mainly in hepatocytes, in biopsies from the patients with different liver diseases. A very large interindividual variation of biochemical liver beta-hexosamindase activity occurred even within the same diagnostic group, andno group of patients showed any significant increase of liver beta-hexosaminidase activity compared with the patients with normal liver histology. Livers with positive immunohistochemistry showed increased biochemical values for beta-hexosaminidase. In patients with cholestasis due to alcohol abuse, the immunohistochemical reaction was intense andthe biochemical beta-hexosaminidase activity was significantly increased compared with non-alcoholic cholestatic cases. Furthermore, blood samples were taken from 50 patients at the same time as the liver biopsies. These patients showed significantly increased serum beta-hexosaminidase activity compared with normal controls, but no correlation wasfound between beta-hexosaminidase activities in the liver and serum of these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:18:14