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Titolo:
LOCALIZATION AND DEVELOPMENTAL EXPRESSION OF THE NMDA RECEPTOR SUBUNIT NR2A IN THE MAMMALIAN RETINA
Autore:
HARTVEIT E; BRANDSTATTER JH; SASSOEPOGNETTO M; LAURIE DJ; SEEBURG PH; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,NEUROANAT ABT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH,NEUROANAT ABT D-60528 FRANKFURT GERMANY UNIV HEIDELBERG,ZMBH,MOLEK NEUROENDOKRINOL LAB D-69120 HEIDELBERG GERMANY
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 348, anno: 1994,
pagine: 570 - 582
SICI:
0021-9967(1994)348:4<570:LADEOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER PLEXIFORM LAYER; D-ASPARTATE RECEPTORS; AMINO-ACID RECEPTORS; ROD BIPOLAR CELLS; ELECTRON-MICROSCOPIC OBSERVATIONS; SELECTIVE GLUTAMATE RECEPTORS; TRANSIENT DENDRITIC SPINES; MOUSE CENTRAL NEURONS; GANGLION-CELLS; RABBIT RETINA;
Keywords:
CAT RETINA; GLUTAMATE RECEPTORS; MONKEY RETINA; RABBIT RETINA; RAT RETINA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
105
Recensione:
Indirizzi per estratti:
Citazione:
E. Hartveit et al., "LOCALIZATION AND DEVELOPMENTAL EXPRESSION OF THE NMDA RECEPTOR SUBUNIT NR2A IN THE MAMMALIAN RETINA", Journal of comparative neurology, 348(4), 1994, pp. 570-582

Abstract

The localization of the N-methyl-D-aspartate receptor subunit NR2A was studied, by using light microscopic immunocytochemistry, in the retina of adult rat, rabbit, cat, and monkey. Strong, punctate immunolabeling was observed in the inner plexiform layer indicating a synaptic localization of the NR2A subunit. The punctate labeling was concentratedin two bands corresponding to the on- and off-sublaminae of the innerplexiform layer. The punctate character of immunofluorescence suggested a synaptic localization of the receptor. This was confirmed by electron microscopy of immunostained adult rat retina. The staining was localized postsynaptic to cone bipolar cells, and only one of the two postsynaptic elements of the dyad was labeled. Staining was not observedat extrasynaptic plasma membranes. In situ hybridization of adult ratretina showed expression of the NR2A subunit in virtually all ganglion cells and displaced amacrine cells in the ganglion cell layer and ina subset of amacrine cells in the inner nuclear layer. The postnatal developmental expression of the NR2A subunit was studied in rat retinaby light microscopic immunocytochemistry. Punctate immunolabeling appeared prior to eye opening, and the developmental profile of NR2A could be compatible with a role in development of circuitry in the inner plexiform layer. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:01:56