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Titolo:
RANDOMIZED CONTROLLED TRIAL OF ENALAPRIL AND BETA-BLOCKERS IN NONDIABETIC CHRONIC-RENAL-FAILURE
Autore:
HANNEDOUCHE T; LANDAIS P; GOLDFARB B; ELESPER N; FOURNIER A; GODIN M; DURAND D; CHANARD J; MIGNON F; SUC JM; GRUNFELD JP;
Indirizzi:
HOP UNIV STRASBOURG,DEPT NEPHROL F-67091 STRASBOURG FRANCE HOP NECKER ENFANTS MALAD,DEPT NEPHROL PARIS FRANCE HOP NECKER ENFANTS MALAD,BIOSTAT LAB PARIS FRANCE HOP SUD,DEPT NEPHROL AMIENS FRANCE HOP BOIS GUILLAUME ROUEN FRANCE HOP RANGUEIL TOULOUSE FRANCE HOP MAISON BLANCHE REIMS FRANCE HOP TERON PARIS FRANCE
Titolo Testata:
BMJ. British medical journal
fascicolo: 6958, volume: 309, anno: 1994,
pagine: 833 - 837
SICI:
0959-8138(1994)309:6958<833:RCTOEA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITORS; BLOOD-PRESSURE; KIDNEY-FUNCTION; ANGIOTENSIN-II; PROGRESSION; DISEASE; HYPERTENSION; NEPHROPATHY; PROTEINURIA; CAPTOPRIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Hannedouche et al., "RANDOMIZED CONTROLLED TRIAL OF ENALAPRIL AND BETA-BLOCKERS IN NONDIABETIC CHRONIC-RENAL-FAILURE", BMJ. British medical journal, 309(6958), 1994, pp. 833-837

Abstract

Objective-To compare the ability of angiotensin converting enzyme inhibitors and beta blockers to slow the development of end stage renal failure in nondiabetic patients with chronic renal failure. Design-Openrandomised multicentre trial with three year follow up. Setting-Outpatient departments of six French hospitals. Patients-100 hypertensive patients with chronic renal failure (initial serum creatinine 200-400 mu mol/l). 52 randomised to enalapril and 48 to beta blockers (conventional treatment). Interventions-Enalapril or beta blocker was combined with frusemide and, if necessary, a calcium blocker or centrally acting drug in patients whose diastolic pressure remained above 90 mm Hg. Results-17 patients receiving conventional treatment and 10 receiving enalapril developed end stage renal failure. The cumulative renal survival rate was significantly better in the enalapril group than in the conventional group P<0.05). The slope of the reciprocal serum creatinine concentration was steeper in the conventionally treated patients (-6.89 x 10(-5)l/mu mol/month) than in the enalapril group (-4.17 x 10(-5)l/mu mol/month; P<0.05). No difference in blood pressure was found between groups. Conclusion-In hypertensive patients with chronic renal failure enalapril slows progression towards end stage renal failure compared with P blockers. This effect was probably not mediated through controlling blood pressure,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:49:49