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Titolo:
FAILURE OF SHORT-TERM CD4-PE40 INFUSIONS TO REDUCE VIRUS LOAD IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS
Autore:
RAMACHANDRAN RV; KATZENSTEIN DA; WOOD R; BATTS DH; MERIGAN TC;
Indirizzi:
STANFORD UNIV,MED CTR,CTR AIDS RES,DIV INFECT DIS,ROOM S-156 STANFORDCA 94305 UPJOHN CO,UPJOHN LABS,CLIN RES 2 INFECT KALAMAZOO MI 49001
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 170, anno: 1994,
pagine: 1009 - 1013
SICI:
0022-1899(1994)170:4<1009:FOSCIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT SOLUBLE CD4; BLOOD MONONUCLEAR-CELLS; CD4-PSEUDOMONAS EXOTOXIN; HIV-INFECTION; TYPE-1;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R.V. Ramachandran et al., "FAILURE OF SHORT-TERM CD4-PE40 INFUSIONS TO REDUCE VIRUS LOAD IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS", The Journal of infectious diseases, 170(4), 1994, pp. 1009-1013

Abstract

The safety, immunologic, and antiviral effects of a recombinant biologic product that combines the second and third domains of the CD4 molecule and Pseudomonas exotoxin A (PE40) were evaluated in 21 human immunodeficiency virus (HIV)-infected subjects in a phase III open-label dose-ranging study. Subjects with CD4(+) lymphocyte counts of 100-500/mm(3) received CD4-PE40 at 40, 80, or 160 mu g/m(2) by infusion three to seven times over 10 days. At the maximum tolerated dose (80 mu g/m(2)), peak CD4-PE40 levels were 65-130 ng/mL with a serum half-life of 3.6 +/- 1.5 h. Toxicity, primarily increased hepatic transaminases, wasdose-related and reversible. HIV DNA proviral levels in peripheral blood mononuclear cells and plasma HIV RNA remained stable during and after CD4-PE40 infusions. The relative resistance of clinical isolates of HIV, limits of the tolerated dose, and the immunogenicity and short half-life of the protein may explain the lack of in vivo antiviral effect of CD4-PE40.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:10:05