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Titolo:
METHIONINE AND CYSTEINE KINETICS AT DIFFERENT INTAKES OF CYSTINE IN HEALTHY ADULT MEN
Autore:
HIRAMATSU T; FUKAGAWA NK; MARCHINI JS; CORTIELLA J; YU YM; CHAPMAN TE; YOUNG VR;
Indirizzi:
MIT,HUMAN NUTR LAB,ROOM E18-613 CAMBRIDGE MA 02139 MIT,HUMAN NUTR LAB CAMBRIDGE MA 02139 MIT,CLIN RES CTR CAMBRIDGE MA 02139
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 4, volume: 60, anno: 1994,
pagine: 525 - 533
SICI:
0002-9165(1994)60:4<525:MACKAD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDISPENSABLE AMINO-ACIDS; RAT HEPATOCYTES; INORGANIC SULFATE; METABOLISM; GLUTATHIONE; HUMANS; LEUCINE; CYSTEINESULFINATE; REQUIREMENTS; CYST(E)INE;
Keywords:
AMINO ACID REQUIREMENTS; SPARING EFFECT; SPLANCHNIC METABOLISM; FIRST PASS REMOVAL; SULFUR AMINO ACIDS; FLUX; OXIDATION; METHIONINE; CYSTEINE; KINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
T. Hiramatsu et al., "METHIONINE AND CYSTEINE KINETICS AT DIFFERENT INTAKES OF CYSTINE IN HEALTHY ADULT MEN", The American journal of clinical nutrition, 60(4), 1994, pp. 525-533

Abstract

We investigated plasma methionine and cys cysteine kinetics in eight healthy adult men receiving for 6 d each of five L-amino acid diets supplying 13 mg methionine.kg(-1).d(-1) without cystine or 6.5 mg methionine.kg(-1).d(-1) plus 0, 5.2, 10.5, or 20.9 mg cystine.kg(-1).d(-1). On the morning of day 7, primed, constant intravenous infusions of L-[H-2(3)-methyl, 1-C-13]methionine and L-[3,3-H-2]cysteine were given for 8 h (for the first 3 h subjects remained in a fasted state and for the next 5 h received small, equal meals at hourly intervals to achievea fed state). Methionine and cysteine fluxes and rate of methionine oxidation were estimated from plasma methionine and cysteine labeling and C-13 in expired air. Methionine oxidation declined (P < 0.05) with lowered methionine intake. Cysteine flux was similar across diets and dietary cystine did not affect tracer methionine oxidation. If there is a sparing effect of dietary cystine on the methionine requirement inadults, it probably takes place during the ''first-pass'' removal of these amino acids within the splanchnic region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:45:58