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Titolo:
FURTHER EVIDENCE THAT THE TACHYCARDIAC RESPONSE TO 5-HYDROXYTRYPTAMINE IN RATS IS NOT MEDIATED VIA TYPICAL 5-HT2 RECEPTORS
Autore:
KRSTIC MK; KATUSIC ZS;
Indirizzi:
FAC MED BELGRADE,DEPT PHARMACOL,POB 662 YU-11000 BELGRADE YUGOSLAVIA
Titolo Testata:
General pharmacology
fascicolo: 5, volume: 25, anno: 1994,
pagine: 917 - 921
SICI:
0306-3623(1994)25:5<917:FETTTR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITHED RAT; HEART; ANTAGONIST; SEROTONIN; AGONIST; DOI;
Keywords:
5-HYDROXYTRYPTAMINE; RAT HEART; KETANSERIN; MESULERGINE; METHIOTHEPIN; 8-OH DPAT; RU 24969; MDL 72222;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Krstic e Z.S. Katusic, "FURTHER EVIDENCE THAT THE TACHYCARDIAC RESPONSE TO 5-HYDROXYTRYPTAMINE IN RATS IS NOT MEDIATED VIA TYPICAL 5-HT2 RECEPTORS", General pharmacology, 25(5), 1994, pp. 917-921

Abstract

1. In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the presser response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3.8-OH DPAT and RU 24969 produced no significant tachycardia, while DOIneither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metociopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:02:21