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Titolo:
RELATIONSHIP BETWEEN PLASMA AND BONE CONCENTRATIONS OF CEFUROXIME ANDFLUCLOXACILLIN
Autore:
FERRERO MMA; VREE TB; KOLMER EWJV; SLOOFF TJJH;
Indirizzi:
ACAD HOSP NIJMEGEN ST RADBOUD,INST ORTHOPED,DEPT CLIN PHARM,GEERT GROOTEPLEIN 8 6525 GA NIJMEGEN NETHERLANDS ACAD HOSP NIJMEGEN ST RADBOUD,INST ORTHOPED,DEPT CLIN PHARM 6525 GA NIJMEGEN NETHERLANDS ACAD HOSP NIJMEGEN ST RADBOUD,INST ANAESHTESIOL 6525 GA NIJMEGEN NETHERLANDS ACAD HOSP NIJMEGEN ST RADBOUD,DEPT CLIN PHARM 6525 GA NIJMEGEN NETHERLANDS
Titolo Testata:
Biopharmaceutics & drug disposition
fascicolo: 7, volume: 15, anno: 1994,
pagine: 599 - 608
SICI:
0142-2782(1994)15:7<599:RBPABC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
KNEE ARTHROPLASTY; JOINT INFECTIONS; PHARMACOKINETICS; TISSUE; PROPHYLAXIS; REPLACEMENT; CEFAMANDOLE; THERAPY; SERUM; HIP;
Keywords:
CEFUROXIME; FLUCLOXACILLIN; BONE CONCENTRATION; PLASMA CONCENTRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.M.A. Ferrero et al., "RELATIONSHIP BETWEEN PLASMA AND BONE CONCENTRATIONS OF CEFUROXIME ANDFLUCLOXACILLIN", Biopharmaceutics & drug disposition, 15(7), 1994, pp. 599-608

Abstract

(i) The objective was to determine the range of bone levels of cefuroxime and flucloxacillin achieved after one intravenous (IV) administration of different dosages of cefuroxime and flucloxacillin. (ii) Six groups of five patients participated in the study. The first three groups (A-C) received respectively 1500 mg, 1000 mg, and 500 mg cefuroximeintravenously and the second three groups (D-F) received 2000 mg, 1500 mg, and 1000 mg flucloxacillin intravenously. (iii) Parenteral administration of cefuroxime and flucloxacillin resulted in measurable boneconcentrations in all patients. (iv) Large inter-individual variationin bone concentration was observed. (v) The bone concentrations of IVcefuroxime were higher (1500 mg, p=0.0057; 1000 mg, p=0.0260) than those of flucloxacillin. The bone concentrations of cefuroxime and flucloxacillin were dose dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:14:15