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Titolo:
STEREOSELECTIVE EFFECTS OF 2,3-BENZODIAZEPINES IN-VIVO - ELECTROPHYSIOLOGY AND NEUROPROTECTION STUDIES
Autore:
LODGE D; BOND A; ONEILL MJ; HICKS CA; JONES MG;
Indirizzi:
ELI LILLY & CO,LILLY RES CTR LTD,ERL WOOD MANOR WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 12, volume: 35, anno: 1996,
pagine: 1681 - 1688
SICI:
0028-3908(1996)35:12<1681:SEO2I->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-NMDA ANTAGONISTS; AMPA KAINATE ANTAGONISTS; GYKI 52466; -DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE NBQX; ANTICONVULSANT ACTIVITY; RECEPTOR ANTAGONISM; FOREBRAIN ISCHEMIA; CEREBRAL-ISCHEMIA; GLOBAL-ISCHEMIA; FOCAL ISCHEMIA;
Keywords:
2,3-BENZODIAZEPINES; AMPA RECEPTOR; SPINAL NEURONS; GLOBAL ISCHEMIA; N-METHYL-D-ASPARTATE (NMDA); KAINATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
D. Lodge et al., "STEREOSELECTIVE EFFECTS OF 2,3-BENZODIAZEPINES IN-VIVO - ELECTROPHYSIOLOGY AND NEUROPROTECTION STUDIES", Neuropharmacology, 35(12), 1996, pp. 1681-1688

Abstract

The stereoselectivity and potency of 3N-substituted 2,3-benzodiazepines were examined in vivo against excitation of spinal neurones inducedby electrophoretic ejection of N-methyl-D-aspartate (NMDA), pha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) and kainate in anaesthetised rats. AMPA receptor antagonist activity resided in the (-) isomers, LY300164 and LY303070, which were effective given electrophoretically, intravenously (2.5-5 mg/kg) or orally (10 mg/kg). The same stereoselectivity was observed in neuroprotection studies. Thus, systemic administration of the (-) isomer, but not the (+) isomer, of these 2,3-benzodiazepines before or immediately after bilateral carotid artery occlusion in the gerbil was neuroprotective. For example, 10 mg/kg of LY300164 intraperitoneally or orally provided survival of up to 25% ofhippocampal CA1 neurones. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:04:27