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Titolo:
T-CELL RECEPTOR-BETA CHAIN GENE REARRANGEMENT AND SELECTION DURING THYMOCYTE DEVELOPMENT IN ADULT MICE
Autore:
DUDLEY EC; PETRIE HT; SHAH LM; OWEN MJ; HAYDAY AC;
Indirizzi:
YALE UNIV,DEPT BIOL,POB 6666 NEW HAVEN CT 06511 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 IMPERIAL CANC RES FUND,LABS LONDON WC2A 3PX ENGLAND YALE UNIV,IMMUNOBIOL SECT NEW HAVEN CT 06511
Titolo Testata:
Immunity
fascicolo: 2, volume: 1, anno: 1994,
pagine: 83 - 93
SICI:
1074-7613(1994)1:2<83:TRCGRA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; IMMATURE THYMOCYTES; ANTIGEN RECEPTOR; ZETA-CHAIN; ALPHA-BETA; INTERLEUKIN-2 RECEPTOR; SURFACE EXPRESSION; ALLELIC EXCLUSION; MURINE THYMOCYTES; MUTANT MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
E.C. Dudley et al., "T-CELL RECEPTOR-BETA CHAIN GENE REARRANGEMENT AND SELECTION DURING THYMOCYTE DEVELOPMENT IN ADULT MICE", Immunity, 1(2), 1994, pp. 83-93

Abstract

The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not preclude differentiation to TCR gamma delta(+) T cells. This is consistent with the view that an initial consequence of beta chain expression by early thymocytes is clonal expansion, increasing the size of the pool of useful precursors. This allows the proposal to be made that allelic exclusion may be a byproduct of cell cycle regulation during early thymocyte differentiation, which may in turn explain why the efficiency of allelic exclusion variesat different TCR or immunoglobulin loci.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:11:23