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Titolo:
ACUTE STROKE INTERVENTION WITH INTRAARTERIAL UROKINASE INFUSION
Autore:
BARR JD; MATHIS JM; WILDENHAIN SL; WECHSLER L; JUNGREIS CA; HORTON JA;
Indirizzi:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL HERSHEY PA 17033 UNIV PITTSBURGH,PRESBYTERIAN UNIV HOSP,DEPT RADIOL PITTSBURGH PA 00000 UNIV PITTSBURGH,PRESBYTERIAN UNIV HOSP,DEPT NEUROL PITTSBURGH PA 00000
Titolo Testata:
Journal of vascular and interventional radiology
fascicolo: 5, volume: 5, anno: 1994,
pagine: 705 - 713
SICI:
1051-0443(1994)5:5<705:ASIWIU>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR; MIDDLE-CEREBRAL-ARTERY; FIBRINOLYTIC THERAPY; BRAIN PROTECTION; PHARMACOLOGICAL CONSIDERATIONS; THROMBOLYTIC THERAPY; CAROTID TERRITORY; CONTROLLED TRIAL; EMBOLIC STROKE; BLOOD-FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Barr et al., "ACUTE STROKE INTERVENTION WITH INTRAARTERIAL UROKINASE INFUSION", Journal of vascular and interventional radiology, 5(5), 1994, pp. 705-713

Abstract

PURPOSE: A preliminary evaluation of the efficacy and safety of treating patients with acute stroke with intraarterial urokinase infusions was performed. PATIENTS AND METHODS: Twelve patients with acute strokewere treated within 8 hours of symptom onset (average, 5 hours). Thrombolysis was performed within the middle cerebral (n = 10), internal carotid (n = 1), and basilar (n = 1) arteries. Urokinase (160,000-500,000 IU) was infused through microcatheters placed into or adjacent to the thrombi. RESULTS: Thrombolysis was angiographically successful in nine patients (75%), all of whom had long-term neurologic improvement. No or minimal neurologic deficits were present in six patients (50%). Thrombolysis failed in three patients (25%); one patient died and two developed severe permanent neurologic deficits. No hemorrhagic complications occurred. CONCLUSION: Preliminary results suggest that intraarterial urokinase infusion may be effective and safe for treating patients with acute stroke. Potentially devastating neurologic damage was averted or lessened in nine patients (75%). No additional neurologic damage was caused by intervention in the remaining three patients (25%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:59:37