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Titolo:
A CANCER-RESEARCH CAMPAIGN (CRC) PHASE-II TRIAL OF CB10-277 GIVEN BY 24-HOUR INFUSION FOR MALIGNANT-MELANOMA
Autore:
BLEEHEN NM; CALVERT AH; LEE SM; HARPER P; KAYE SB; JUDSON I; BRAMPTON M;
Indirizzi:
UNIV CAMBRIDGE,DEPT CLIN ONCOL & RADIOTHERAPEUT CAMBRIDGE CB2 2QQ ENGLAND UNIV NEWCASTLE UPON TYNE,DIV ONCOL,CANC RES UNIT NEWCASTLE TYNE NE2 4HH ENGLAND CHRISTIE HOSP,DEPT MED ONCOL MANCHESTER M20 9BX LANCS ENGLAND GUYS HOSP,DEPT MED ONCOL LONDON SE1 9RT ENGLAND WESTERN INFIRM & ASSOCIATED HOSP,BEATSON ONCOL CTR GLASGOW G11 6NT SCOTLAND INST CANC RES SUTTON SM2 5NG SURREY ENGLAND CHARING CROSS HOSP,CRC,CTR DATA,DEPT MED ONCOL LONDON W6 8RF ENGLAND ADDENBROOKES HOSP,MRC,CLIN ONCOL & RADIOTHERAPEUT UNIT CAMBRIDGE CB2 2QQ ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 4, volume: 70, anno: 1994,
pagine: 775 - 777
SICI:
0007-0920(1994)70:4<775:ACC(PT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR INHIBITORY TRIAZENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
N.M. Bleehen et al., "A CANCER-RESEARCH CAMPAIGN (CRC) PHASE-II TRIAL OF CB10-277 GIVEN BY 24-HOUR INFUSION FOR MALIGNANT-MELANOMA", British Journal of Cancer, 70(4), 1994, pp. 775-777

Abstract

The dacarbazine analogue CB10-277 has been investigated for anti-tumour activity in a phase II study on malignant melanoma. Treatment was administered as a slow infusion of 12,000 mg m(-2) over 24 h and repeated every 3 weeks. A total of 28 patients were entered into the study, of whom 23 were eligible for review. A total of 64 courses was given. There was one objective partial response in 22 patients assessable forresponse. The major toxicities were leucopenia and thrombocytopenia. CB10-277 in this schedule therefore does not appear to have major activity in melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:15:25