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Titolo:
SUPERSENSITIVE DILATOR RESPONSE TO NITROGLYCERIN BUT NOT TO ATRIAL-NATRIURETIC-PEPTIDE IN SPASTIC CORONARY-ARTERIES IN CORONARY SPASTIC ANGINA
Autore:
KUGIYAMA K; OHGUSHI M; SUGIYAMA S; MOTOYAMA T; KAWANO H; HIRASHIMA O; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,1-1-1 HONJO KUMAMOTO 860 JAPAN
Titolo Testata:
The American journal of cardiology
fascicolo: 5, volume: 79, anno: 1997,
pagine: 606 - 610
SICI:
0002-9149(1997)79:5<606:SDRTNB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE SYNTHESIS; VARIANT ANGINA; MOLECULAR-CLONING; ACETYLCHOLINE; INHIBITION; ATHEROSCLEROSIS; PATHOGENESIS; INJECTION; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K. Kugiyama et al., "SUPERSENSITIVE DILATOR RESPONSE TO NITROGLYCERIN BUT NOT TO ATRIAL-NATRIURETIC-PEPTIDE IN SPASTIC CORONARY-ARTERIES IN CORONARY SPASTIC ANGINA", The American journal of cardiology, 79(5), 1997, pp. 606-610

Abstract

It has been shown that there is the supersensitivity of the dilator effect of nitrovasodilators in the coronary arteries of patients with coronary spastic angina. This study was aimed to elucidate its mechanism(s) by examination of dilator response of spastic coronary arteries to atrial natriuretic peptide (ANP), which is known to dilate arteries by the same final common pathway through cyclic guanosine monophosphate (cGMP) as nitrovasodilators. Effects of infusion of nitroglycerin and ANP on epicardial coronary diameter of left coronary arteries were thus examined by quantitative coronary angiography in 20 patients with coronary spastic angina, who had spasm in left coronary arteries, and in 27 control subjects. Dilator response of coronary diameter to intracoronary infusion of ANP (0.5 mu g/kg) was found to be comparable between spastic coronary arteries and control arteries, whereas dilator response to nitroglycerin (250 mu g) was enhanced in the spastic arteries compared with control arteries. The results indicate that spastic coronary arteries exhibit supersensitive dilator response to nitroglycerin but not to ANP. There is a possibility that dilator response to cGMP may be comparable between spastic and control coronary arteries and that soluble guanylate cyclase activity and/or conversion of nitric oxide bioactivity from nitroglycerin may be enhanced in spastic coronaryarteries. (C) 1997 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:56:33