Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IS THERE A ROLE FOR BRADYKININ IN THE THERAPEUTIC AND SIDE-EFFECTS OFANGIOTENSIN-CONVERTING ENZYME-INHIBITORS
Autore:
MARCEAU F;
Indirizzi:
UNIV QUEBEC,CTR HOSP,CTR RECH PAVILLON HDQ,11 COTE PALAIS QUEBEC CITYPQ G1R 2J6 CANADA
Titolo Testata:
Canadian journal of cardiology
fascicolo: 2, volume: 13, anno: 1997,
pagine: 187 - 194
SICI:
0828-282X(1997)13:2<187:ITARFB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORONARY-ARTERIES; VASCULAR SMOOTH-MUSCLE; INTRADERMAL BRADYKININ; ACE-INHIBITOR; ANAPHYLACTOID REACTIONS; INDUCED VASODILATION; ASTHMATIC SUBJECTS; TISSUE KALLIKREIN; KININS; CAPTOPRIL;
Keywords:
ANGIOTENSIN CONVERTING ENZYME INHIBITORS; BRADYKININ; HOE 140 (ICATIBANT); KALLIKREIN-KININ SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
F. Marceau, "IS THERE A ROLE FOR BRADYKININ IN THE THERAPEUTIC AND SIDE-EFFECTS OFANGIOTENSIN-CONVERTING ENZYME-INHIBITORS", Canadian journal of cardiology, 13(2), 1997, pp. 187-194

Abstract

OBJECTIVE: To review critically the persistent suggestion that at least a pan of the beneficial and side effects of angiotensin I converting enzyme inhibitors (ACEIs) is derived from the potentiation of endogenous bradykinin (BK). DATA SOURCES: Selected clinical studies of the pharmacology and analytical biochemistry of the kallikrein-kinin system, current literature on novel drugs binding to receptors for BK and angiotensin II, and a few animal studies when clinical data were not available. DATA EXTRACTION: Current concepts of the kallikrein-kinin system and related analytical/pharmacological tools are briefly reviewed and applied to the analysis of the role of endogenous kinins in the therapeutic and side effects of ACEIs. DATA SYNTHESIS: The development ofeffective BK antagonists is recent and provides novel opportunities to assess the role of BK in physiology and pathology. The role of BK asan inflammatory mediator is relatively well understood, and current drug development programs for kinin receptor agonists and antagonists are focused on the inflammatory pharmacological profile of kinins. The kallikrein-kinin system may not be active to a significant degree in normal individuals, but rather recruited during tissue injury or by specific physiological conditions (such as high sodium intake). The role of BK in some inflammatory/anaphylactoid side effects of ACEIs is not firmly established, but possible. The role of BK in the therapeutic effects of ACEIs depends on the model in animal studies and is likely tobe modest in essential hypertension. CONCLUSION: Several methodological problems have delayed the progress of clinical research of the kallikrein-kinin system. While ACEIs clearly potentiate the tissue effectsof exogenous BK, the role of endogenous BK in the normal and pathological circulation is still uncertain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:41:54