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Titolo:
CLINICAL FACTORS ASSOCIATED WITH CALCIFIC AORTIC-VALVE DISEASE
Autore:
STEWART BF; SISCOVICK D; LIND BK; GARDIN JM; GOTTDIENER JS; SMITH VE; KITZMAN DW; OTTO CM;
Indirizzi:
UNIV WASHINGTON,DEPT MED,DIV CARDIOL,BOX 356422 SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED,DIV CARDIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL & BIOSTAT,DIV CARDIOL SEATTLE WA 98195 UNIV CALIF IRVINE,DIV CARDIOL ORANGE CA 92668 GEORGETOWN UNIV HOSP,DIV CARDIOL WASHINGTON DC 20007 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,CARDIOL SECT WINSTON SALEM NC 27103 ALBANY MED COLL,DIV CARDIOL ALBANY NY 12208
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 3, volume: 29, anno: 1997,
pagine: 630 - 634
SICI:
0735-1097(1997)29:3<630:CFAWCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; RISK-FACTORS; STENOSIS; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; PREVALENCE; EXPRESSION; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B.F. Stewart et al., "CLINICAL FACTORS ASSOCIATED WITH CALCIFIC AORTIC-VALVE DISEASE", Journal of the American College of Cardiology, 29(3), 1997, pp. 630-634

Abstract

Objectives. The aim of this study was to determine the prevalence of aortic sclerosis and stenosis in the elderly and to identify clinical factors associated with degenerative aortic valve disease. Background. Several lines of evidence suggest that degenerative aortic valve disease is not an inevitable consequence of aging and may be associated with specific clinical factors. Methods. In 5,201 subjects greater than or equal to 65 years of age enrolled in the Cardiovascular Health Study, the relation between aortic sclerosis or stenosis identified on echocardiography and clinical risk factors for atherosclerosis was evaluated by using stepwise logistic regression analysis. Results. Aortic value sclerosis was present in 26% and aortic valve stenosis in 2% of the entire study cohort; in subjects greater than or equal to 75 years of age, sclerosis was present in 37% and stenosis in 2.6%. Independent clinical factors associated with degenerative aortic valve disease included age (twofold increased risk for each 10-year increase in age), male gender (twofold excess risk), present smoking (35% increase in risk) and a history of hypertension (20% increase in risk), Other significant factors included height and high lipoprotein(a) and low density lipoprotein cholesterol levels. Conclusions. Clinical factors associated with aortic sclerosis and stenosis can be identified and are similarto risk factors for atherosclerosis. (C) 1997 by the American Collegeof Cardiology.

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Documento generato il 24/11/20 alle ore 07:58:03