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Titolo:
ADENOSINE A(3) RECEPTOR STIMULATION AND CEREBRAL-ISCHEMIA
Autore:
VONLUBITZ DKJE; LIN RCS; POPIK P; CARTER MF; JACOBSON KA;
Indirizzi:
NIDDK,BIOORGAN CHEM LAB,MOLEC RECOGNIT SECT,BLDG 8,RM 111 BETHESDA MD20892 HAHNEMANN UNIV,DEPT PHYSIOL & BIOPHYS PHILADELPHIA PA 19102 NIDDK,NEUROSCI LAB BETHESDA MD 20892
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 263, anno: 1994,
pagine: 59 - 67
SICI:
0014-2999(1994)263:1-2<59:AARSAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; FOREBRAIN ISCHEMIA; BLOOD-FLOW; RAT-BRAIN; RESUSCITATION; SEIZURES; GLUCOSE; THERAPY; ARREST; NUMBER;
Keywords:
ADENOSINE RECEPTOR; BRAIN ISCHEMIA, THERAPY; CEREBRAL BLOOD FLOW; (GERBIL);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
D.K.J.E. Vonlubitz et al., "ADENOSINE A(3) RECEPTOR STIMULATION AND CEREBRAL-ISCHEMIA", European journal of pharmacology, 263(1-2), 1994, pp. 59-67

Abstract

Chronic treatment with the selective adenosine A(3) receptor agonist N-6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) administered prior to either 10 or 20 min forebrain ischemia in gerbils resulted in improved postischemic cerebral blood circulation, survival, and neuronal preservation. Opposite effects, i.e., impaired postischemic blood flow, enhanced mortality, and extensive neuronal destruction in the hippocampus were seen when IB-MECA was given acutely. Neither adenosine A(1) nor A(2) receptors are involved in these actions. The data indicate that stimulation of adenosine A(3) receptors may play an important role in the development of ischemic damage, and that adenosine A(3) receptors may offer a new target for therapeutic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 09:02:01