Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISTRIBUTION OF DOMINANT T-CELL RECEPTOR-BETA CHAINS IN HUMAN INTESTINAL-MUCOSA
Autore:
GROSS GG; SCHWARTZ VL; STEVENS C; EBERT EC; BLUMBERG RS; BALK SP;
Indirizzi:
BETH ISRAEL HOSP,DIV HEMATOL ONCOL,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DIV HEMATOL ONCOL BOSTON MA 02215 BETH ISRAEL HOSP,DIV GASTROENTEROL BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 02215 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DIV GASTROENTEROL NEW BRUNSWICK NJ 08903 BRIGHAM & WOMENS HOSP,DIV GASTROENTEROL BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
The Journal of experimental medicine
fascicolo: 4, volume: 180, anno: 1994,
pagine: 1337 - 1344
SICI:
0022-1007(1994)180:4<1337:DODTRC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN INTRAEPITHELIAL LYMPHOCYTES; CD8 ACCESSORY MOLECULE; NORMAL HUMAN-SKIN; ALPHA-BETA; PERIPHERAL-BLOOD; GAMMA-DELTA; ANTIGEN RECEPTOR; EXPRESSION; COUNTERPARTS; CLONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
G.G. Gross et al., "DISTRIBUTION OF DOMINANT T-CELL RECEPTOR-BETA CHAINS IN HUMAN INTESTINAL-MUCOSA", The Journal of experimental medicine, 180(4), 1994, pp. 1337-1344

Abstract

The majority of human intestinal intraepithelial lymphocytes (iIELs) are CD8(+) T cells that use the T cell receptor (TCR)-alpha/beta. Previous studies have shown that iIELs isolated from segments of small intestine or colon contain one or several dominant alpha/beta T cell clones. It is not known whether these clones expand only locally in response to a particular antigen or whether they are widely distributed throughout the intestine. To address this question, iIELs were purified from near the proximal and distal margins in a series of intestinal resections for noninflammatory diseases. TCR-beta expression was then assessed by semiquantitative polymerase chain reaction amplification, analysis of N-region length, and DNA sequencing. The previously described oligoclonal expansion of iIELs was confirmed in each sample. Identicaldominant clones were identified in the proximal and distal samples from most cases, including samples taken from sites as distant as the transverse and sigmoid colon or rectum. Distinct clones were found in only one case with samples from the terminal ileum and transverse colon. These results demonstrate that a relatively small number of widely dispersed T cell clones comprise the majority of cells in the human intestinal mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:23:28