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Titolo:
GROUP-I METABOTROPIC GLUTAMATE RECEPTORS MGLUR1-ALPHA AND MGLUR5A - LOCALIZATION IN BOTH SYNAPTIC LAYERS OF THE RAT RETINA
Autore:
KOULEN P; KUHN R; WASSLE H; BRANDSTATTER JH;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH,ABT NEUROANAT D-60528 FRANKFURT GERMANY CIBA GEIGY AG,CNS RES CH-4002 BASEL SWITZERLAND
Titolo Testata:
The Journal of neuroscience
fascicolo: 6, volume: 17, anno: 1997,
pagine: 2200 - 2211
SICI:
0270-6474(1997)17:6<2200:GMGRMA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROD BIPOLAR CELLS; PROTEIN-KINASE-C; SIGNAL-TRANSDUCTION; MAMMALIAN RETINA; MOLECULAR CHARACTERIZATION; VERTEBRATE RETINA; IMMUNOCYTOCHEMICAL LOCALIZATION; AMACRINE CELL; EXPRESSION; IMMUNOREACTIVITY;
Keywords:
MGLUR1-ALPHA; MGLUR5A; BIPOLAR CELLS; AMACRINE CELLS; OUTER PLEXIFORM LAYER; INNER PLEXIFORM LAYER; RAT RETINA; RETINAL DEVELOPMENT; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
P. Koulen et al., "GROUP-I METABOTROPIC GLUTAMATE RECEPTORS MGLUR1-ALPHA AND MGLUR5A - LOCALIZATION IN BOTH SYNAPTIC LAYERS OF THE RAT RETINA", The Journal of neuroscience, 17(6), 1997, pp. 2200-2211

Abstract

We examined the distribution of the group I metabotropic glutamate receptors, mGluR1 alpha and mGluR5a, in the adult rat retina and during postnatal development using receptor-specific antisera. In contrast tothe restricted localization of group II and group III mGluRs to either the outer plexiform layer (OPL) or the inner plexiform layer (IPL), group I mGluRs are present in both synaptic layers in the rat retina. Double-labeling experiments and electron microscopy showed that in theOPL the two receptors are localized on the dendritic tips of bipolar cells postsynaptic to photoreceptor terminals. In the IPL the two mGluRs are localized on amacrine cell processes postsynaptic to bipolar cell terminals. These results suggest that group I mGluRs are involved in synaptic processing in both plexiform layers and in both the scotopic and photopic pathways in the rat retina. We propose that mGluR1 alpha and mGluR5a play an important modulatory role in the responses of retinal neurons to inhibitory and excitatory neurotransmitters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:42:54