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Titolo:
INTERCONNECTED PARALLEL CIRCUITS BETWEEN RAT NUCLEUS-ACCUMBENS AND THALAMUS REVEALED BY RETROGRADE TRANSYNAPTIC TRANSPORT OF PSEUDORABIES VIRUS
Autore:
ODONNELL P; LAVIN A; ENQUIST LW; GRACE AA; CARD JP;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI,CTR NEUROSCI,446 CRAWFORD HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PSYCHIAT,CTR NEUROSCI PITTSBURGH PA 15260 PRINCETON UNIV,DEPT MOL BIOL PRINCETON NJ 08544
Titolo Testata:
The Journal of neuroscience
fascicolo: 6, volume: 17, anno: 1997,
pagine: 2143 - 2167
SICI:
0270-6474(1997)17:6<2143:IPCBRN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BASAL GANGLIA; PREFRONTAL CORTEX; VENTRAL PALLIDUM; EFFERENT PROJECTIONS; TOPOGRAPHICAL ORGANIZATION; TRANSNEURONAL TRANSPORT; IMMUNOREACTIVE BOUTONS; HORSERADISH-PEROXIDASE; STRIATOPALLIDAL SYSTEM;
Keywords:
TRANSNEURONAL TRACING; RETICULAR THALAMIC NUCLEUS; VENTRAL PALLIDUM; NUCLEUS ACCUMBENS; MEDIODORSAL THALAMIC NUCLEUS; PREFRONTAL CORTEX; GLOBUS PALLIDUS; PSEUDORABIES VIRUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
129
Recensione:
Indirizzi per estratti:
Citazione:
P. Odonnell et al., "INTERCONNECTED PARALLEL CIRCUITS BETWEEN RAT NUCLEUS-ACCUMBENS AND THALAMUS REVEALED BY RETROGRADE TRANSYNAPTIC TRANSPORT OF PSEUDORABIES VIRUS", The Journal of neuroscience, 17(6), 1997, pp. 2143-2167

Abstract

One of the primary outputs of the nucleus accumbens is directed to the mediodorsal thalamic nucleus (MD) via its projections to the ventralpallidum (VP), with the core and shell regions of the accumbens projecting to the lateral and medial aspects of the VP, respectively. In this study, the multisynaptic organization of nucleus accumbens projections was assessed using intracerebral injections of an attenuated strain of pseudorabies virus, a neurotropic alpha herpesvirus that replicates in synaptically linked neurons. Injection of pseudorabies virus into different regions of the MD or reticular thalamic nucleus (RTN) produced retrograde transynaptic infections that revealed multisynaptic interactions between these areas and the basal forebrain. Immunohistochemical localization of viral antigen at short postinoculation intervalsconfirmed that the medial MD (m-MD) receives direct projections from the medial VP, rostral RTN, and other regions previously shown to project to this region of the thalamus. At longer survival intervals, injections confined to the m-MD resulted in transynaptic infection of neurons in the accumbens shell but not in the core. Injections that also included the central segment of the MD produced retrograde infection ofneurons in the lateral VP and the polymorph (pallidal) region of the olfactory tubercle (OT) and transynaptic infection of a small number of neurons in the rostral accumbens core. Injections in the lateral MD resulted in retrograde infection in the globus pallidus (GP) and in transynaptic infection in the caudate-putamen. Viral injections into therostroventral pole of the RTN infected neurons in the medial and lateral VP and at longer postinoculation intervals, led to transynaptic infection of scattered neurons in the shell and core. Injection of virusinto the intermediate RTN resulted in infection of medial VP neurons and second-order infection of neurons in the accumbens shell. Injections in the caudal RTN or the lateral MD resulted in direct retrograde labeling of cells within the GP and transynaptic infection of neurons in the caudate-putamen. These results indicate that the main output of VP neurons receiving inputs from the shell of the accumbens is heavilydirected to the m-MD, whereas a small number of core neurons appear to influence the central MD via the lateral VP. Further segregation in the flow of information to the MD is apparent in the organization of VP and GP projections to subdivisions of the RTN that give rise to MD afferents. Collectively, these data provide a morphological basis for the control of the thalamocortical system by ventral striatal regions, in which parallel connections to the RTN may exert control over activity states of cortical regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 20:43:07