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Titolo:
GENETIC CHANGES IN ATYPICAL HYPERPLASIA AND LYMPHOMA WITH ANGIOIMMUNOBLASTIC LYMPHADENOPATHY AND DYSPROTEINEMIA IN THE SAME PATIENTS
Autore:
OHSHIMA K; KIKUCHI M; HASHIMOTO M; KOZURU M; UIKE N; KOBARI SI; MASUDA Y; SUMIYOSHI Y; YONEDA S; TAKESHITA M; KIMURA N;
Indirizzi:
FUKUOKA UNIV,SCH MED,DEPT PATHOL,JYONAN KU,NANAKUMA 7-45-1 FUKUOKA 81401 JAPAN FUKUOKA UNIV,SCH MED,DEPT INTERNAL MED FUKUOKA 81401 JAPAN KYUSHU CANC CTR HOSP,HAEMATOL SECT FUKUOKA JAPAN
Titolo Testata:
Virchows Archiv
fascicolo: 1, volume: 425, anno: 1994,
pagine: 25 - 32
SICI:
0945-6317(1994)425:1<25:GCIAHA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; RECEPTOR BETA-CHAIN; T-CELL LYMPHOMAS; LYMPHOPROLIFERATIVE DISORDERS; LYMPHOEPITHELIOID LYMPHOMA; MALIGNANT-LYMPHOMA; ZONE LYMPHOMA; LOW-GRADE; REARRANGEMENT; IMMUNOGLOBULIN;
Keywords:
ANGIOIMMUNOBLASTIC; LYMPHADENOPATHY WITH DYSPROTEINEMIA; POLYMERASE CHAIN REACTION; T-CELL RECEPTOR GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohshima et al., "GENETIC CHANGES IN ATYPICAL HYPERPLASIA AND LYMPHOMA WITH ANGIOIMMUNOBLASTIC LYMPHADENOPATHY AND DYSPROTEINEMIA IN THE SAME PATIENTS", Virchows Archiv, 425(1), 1994, pp. 25-32

Abstract

The transition between atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia (AILD) was studied in serial lymp node biopsy specimens from five patients using DNA analysis with Southern blot analysis, polymerase chain reaction, chromosomal analysis, and immunophenotyping. The chromosomal analysis showed additional abnormalities as the disease progressed to those present initially, and immunological staining showed a corresponding increase in the numbers of CD4- and Ki67-positive cells. In the first biopsy from eachpatient a diagnosis of atypical hyperplasia with AILD was made and lymphoma excluding by the finding of only a few atypical lymphoid cells and the preservation of follicles with germinal centres. DNA analysis of lymph nodes at this stage showed either germ lines or oligoclonal rearrangements of the T-cell receptor (TCR) and immunoglobulin heavy chain genes. In the final biopsy, when a diagnosis of lymphoma with AILDwas made, either a monoclonal rearrangement of the TCR was observed or one of the rearranged bands had increased in density. These results suggest selective proliferation of a clone of abnormal cells may account for the progression of atypical hyperplasia to lymphoma with AILD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:30:01