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Titolo:
HIGH IGE SERUM LEVELS AND PEPTIC-ULCERS - CLINICAL AND FUNCTIONAL-APPROACH
Autore:
DELAZZARI F; MANCIN O; PLEBANI M; VENTURI C; BATTAGLIA G; VIANELLO F; GALLIANI EA; DIMARIO F; NACCARATO R;
Indirizzi:
UNIV PADUA,IST MED INTERNA,VIA GIUSTINIANI 2 I-35128 PADUA ITALY UNIV PADUA,IST MED LAB I-35128 PADUA ITALY
Titolo Testata:
The Italian Journal of Gastroenterology
fascicolo: 1, volume: 26, anno: 1994,
pagine: 7 - 11
SICI:
0392-0623(1994)26:1<7:HISLAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD ALLERGY; CELLS; TESTS;
Keywords:
GASTRIC FUNCTION; PEPTIC ULCER; SERUM IGE LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F. Delazzari et al., "HIGH IGE SERUM LEVELS AND PEPTIC-ULCERS - CLINICAL AND FUNCTIONAL-APPROACH", The Italian Journal of Gastroenterology, 26(1), 1994, pp. 7-11

Abstract

The prevalence of high total IgE serum levels was evaluated in 232 consecutive patients suffering from peptic ulcer. Twenty-one percent of the patients presented total IgE serum levels above 200 KU/L compared with the 5% found in a healthy control population (p<0.004). Similar prevalence was found in gastric and/or duodenal ulcers. No significant differences in the duration of the disease, smoking habits, familiarity for peptic ulcer, symptomatology and frequency of complications wereobserved between patients with high and with normal total IgE serum levels. Gastric function studies (gastric acid secretion, serum pepsinogen and gastrin levels) did not show any significant differences between the two groups. The incidence of Helicobacter pylori infection was 65% in patients with normal IgE levels and 75% in those with high IgE levels (p: n.s.). The response to treatment with full dose of H2-receptor antagonists was comparable in both groups (91.25% and 90.7% of ulcer healing after 6-8 weeks of treatment). A relapse of the ulcer after6 months of maintenance therapy (half dose of H2-receptor antagonists) was observed in 39.5% of the patients with ulcer and high total IgE serum as against the 11.9% observed in patients with normal IgE (p<0.001). These data lend further support to the hypothesis of an underlying immuno-allergic reaction in some forms of gastric or duodenal ulcer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:53:53