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Titolo:
IN-VITRO AUTORADIOGRAPHIC LOCALIZATION OF AMYLIN BINDING-SITES IN RAT-BRAIN
Autore:
SEXTON PM; PAXINOS G; KENNEY MA; WOOKEY PJ; BEAUMONT K;
Indirizzi:
AMYLIN PHARMACEUT INC,9373 TOWNE CTR DR SAN DIEGO CA 92121 AMYLIN PHARMACEUT INC SAN DIEGO CA 92121 ST VINCENTS INST MED RES FITZROY VIC 3065 AUSTRALIA UNIV NEW S WALES,SCH PSYCHOL KENSINGTON NSW 2033 AUSTRALIA UNIV MELBOURNE,REPATRIAT GEN HOSP,DEPT MED HEIDELBERG VIC 3081 AUSTRALIA
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 62, anno: 1994,
pagine: 553 - 567
SICI:
0306-4522(1994)62:2<553:IALOAB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; CENTRAL-NERVOUS-SYSTEM; ISLET AMYLOID POLYPEPTIDE; SALMON-CALCITONIN; INVITRO AUTORADIOGRAPHY; REGIONAL DISTRIBUTION; SKELETAL-MUSCLE; HIGH-AFFINITY; INVIVO; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Sexton et al., "IN-VITRO AUTORADIOGRAPHIC LOCALIZATION OF AMYLIN BINDING-SITES IN RAT-BRAIN", Neuroscience, 62(2), 1994, pp. 553-567

Abstract

Amylin is a recently discovered 37 amino acid peptide which is co-secreted from the pancreas with insulin and acts to modulate carbohydratemetabolism Recently, high-affinity binding sites for [I-125]rat amylin have been identified in the rat central nervous system. These sites also have high affinity for the structurally related peptides calcitonin gene-related peptide and salmon calcitonin. In the present study wehave used in vitro autoradiography to map the distribution of these [I-125]rat amylin binding sites in rat brain. High to moderate levels of binding were present in mid-caudal accumbens nucleus, fundus striatiand parts of the bed nucleus of the stria terminalis and substantia inominata. This binding extended caudally into parts of the amygdalostriatal transition zone and the central and medial amygdaloid nuclei. High to moderate levels of binding also occurred in much of the hypothalamus including the medial preoptic, dorsomedial hypothalamic and medial tuberal nuclei as well as the ventrolateral subnucleus of the ventromedial hypothalamic nucleus. Other regions of high level binding included the subfornical organ, the vascular organ of the lamina terminalis, area postrema, locus coeruleus, dorsal raphe and caudal parts of thenucleus of the solitary tract. The subfornical organ, vascular organ of the lamina terminalis and area postrema, which display some of the highest binding densities, lack a patent blood-brain barrier and thus could be responsive to blood-borne amylin. In conclusion we have mapped, in detail, the distribution of amylin binding sites in rat brain. The location of binding is consistent with potential roles for these sites in appetite, fluid and electrolyte homeostasis, autonomic functionand regulation of mood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:13:43