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Titolo:
CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED T-CELL FUNCTION IN CD4-DEFICIENT MICE
Autore:
RAHEMTULLA A; KUNDIG TM; NARENDRAN A; BACHMANN MF; JULIUS M; PAIGE CJ; OHASHI PS; ZINKERNAGEL RM; MAK TW;
Indirizzi:
UNIV TORONTO,ONTARIO CANC INST,DEPT MED BIOPHYS & IMMUNOL,500 SHERBOURNE ST TORONTO M4X 1K9 ON CANADA UNIV TORONTO,ONTARIO CANC INST,DEPT MED BIOPHYS & IMMUNOL TORONTO M4X1K9 ON CANADA UNIV ZURICH,INST EXPTL IMMUNOL CH-8091 ZURICH SWITZERLAND WELLESLEY COLL HOSP,RES INST TORONTO ON CANADA AMGEN INST TORONTO ON CANADA
Titolo Testata:
European Journal of Immunology
fascicolo: 9, volume: 24, anno: 1994,
pagine: 2213 - 2218
SICI:
0014-2980(1994)24:9<2213:CMHCTF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR STOMATITIS-VIRUS; LYMPHOCYTE SPECIFICITY; MONOCLONAL-ANTIBODIES; REGULATED EXPRESSION; IMMATURE THYMOCYTES; GENE-PRODUCTS; STEM-CELLS; RECEPTOR; ANTIGENS; CD4;
Keywords:
CD4-DEFICIENT MICE; HELPER T CELLS; IMMUNOGLOBULIN CLASS-SWITCHING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Rahemtulla et al., "CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED T-CELL FUNCTION IN CD4-DEFICIENT MICE", European Journal of Immunology, 24(9), 1994, pp. 2213-2218

Abstract

Previously, we and others have demonstrated that CD4-deficient mice have a normal number of T cells and B cells with a significant population of CD4(-)8(-)TcR alpha beta(+) T cells. Surprisingly, however, these mice lacking CD4 show in vivo immunoglobulin isotype class switchingfrom IgM to IgG in response to sheep erythrocytes and vesicular stomatitis virus. In this study we have depleted various subpopulations of T cells in vivo and shown that the population of CD4(-)8(-)TcR alpha beta(+) T cells is responsible for providing ''help'' in the antibody response of CD4-deficient mice to vesicular stomatitis virus infection. We have used antigen-specific proliferation assays and blocking studies with class I and II major histocompatibility complex (MHC)-specificpurified antibodies to show that these cells are class II MHC-restricted in responses against the T cell-dependent antigen keyhole limpet hemocyanin (KLH). Finally, phenotypic analysis of the CD4(-) CD8(-)thymocytes in CD4-deficient mice shows that these cells have a more maturephenotype than the CD4(-)8(-) thymocytes in wild type mice. These results indicate that CD4 is not absolutely necessary for positive selection or effector function of class II MHC-restricted helper T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:54:56