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Titolo:
IDENTIFICATION OF PRO-THYMOCYTES IN MURINE FETAL BLOOD - T-LINEAGE COMMITMENT CAN PRECEDE THYMUS COLONIZATION
Autore:
RODEWALD HR; KRETZSCHMAR K; TAKEDA S; HOHL C; DESSING M;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND
Titolo Testata:
EMBO journal
fascicolo: 18, volume: 13, anno: 1994,
pagine: 4229 - 4240
SICI:
0261-4189(1994)13:18<4229:IOPIMF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; RECEPTOR BETA-CHAIN; UMBILICAL-CORD BLOOD; COLONY-FORMING CELLS; STEM-CELLS; C-KIT; MONOCLONAL-ANTIBODY; MOLECULAR-GENETICS; LYMPHOCYTES-T; LYMPHOID DIFFERENTIATION;
Keywords:
FETAL BLOOD; HEMATOPOIESIS; PRO-THYMOCYTES; T LINEAGE COMMITMENT; THYMUS COLONIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald et al., "IDENTIFICATION OF PRO-THYMOCYTES IN MURINE FETAL BLOOD - T-LINEAGE COMMITMENT CAN PRECEDE THYMUS COLONIZATION", EMBO journal, 13(18), 1994, pp. 4229-4240

Abstract

Phenotype and commitment of thymus-colonizing precursors are unknown. Here we report the identification of T lineage-committed precursors (designated prothymocytes) in murine fetal blood at day 15.5 of development, Fetal blood pro-thymocytes are Thy-1(+)c-kit(low)CD3(-) in contrast to fetal blood-derived pluripotent hematopoietic progenitors whichare Thy-1(-)c-kit(+). Upon transfer into the thymus, fetal blood pro-thymocytes generate a single wave of CD4(+) CD8(+) thymocytes and subsequently mature TCR alpha beta(+) peripheral T cells, However, fetal blood pro-thymocytes lack multipotent progenitor potential since,they fail to reconstitute B lymphocytes and myeloid and erythroid lineages. in contrast, T and B lymphocytes as well as myeloid and erythroid lineages are reconstituted from fetal blood-derived pluripotent progenitors. Pro-thymocytes are equally present in peripheral blood of athymic fetal mice, suggesting that this novel precursor population is T lineage-committed prior to thymus colonization and represents the earliest Tlineage precursor identified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:10:38