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Titolo:
CORRELATION OF REGIONAL CEREBRAL BLOOD-FLOW EQUIVALENTS MEASURED BY SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY WITH P300 LATENCY AND EYE-MOVEMENT ABNORMALITY IN SCHIZOPHRENIA
Autore:
BLACKWOOD DHR; EBMEIER KP; MUIR WJ; SHARP CW; GLABUS M; WALKER M; SOUZA V; DUNAN JR; GOODWIN GM;
Indirizzi:
UNIV EDINBURGH,ROYAL EDINBURGH HOSP,DEPT PSYCHIAT,MORNINGSIDE PK EDINBURGH EH10 5HF MIDLOTHIAN SCOTLAND ROYAL INFIRM,DEPT MED PHYS EDINBURGH MIDLOTHIAN SCOTLAND ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
Acta psychiatrica Scandinavica
fascicolo: 3, volume: 90, anno: 1994,
pagine: 157 - 166
SICI:
0001-690X(1994)90:3<157:CORCBE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; SUPERIOR TEMPORAL GYRUS; TRACKING DYSFUNCTION; EVOKED-POTENTIALS; BRAIN POTENTIALS; AFFECTIVE-DISORDER; PARIETAL LOBE; PURSUIT; COMPONENTS; MORPHOLOGY;
Keywords:
SCHIZOPHRENIA; CEREBRAL BLOOD FLOW; EYE TRACKING; EVENT-RELATED POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
D.H.R. Blackwood et al., "CORRELATION OF REGIONAL CEREBRAL BLOOD-FLOW EQUIVALENTS MEASURED BY SINGLE-PHOTON EMISSION COMPUTERIZED-TOMOGRAPHY WITH P300 LATENCY AND EYE-MOVEMENT ABNORMALITY IN SCHIZOPHRENIA", Acta psychiatrica Scandinavica, 90(3), 1994, pp. 157-166

Abstract

Single photon emission tomography with the intravenous blood flow marker Tc-99m-exametazime was carried out in 14 acutely ill drug-free schizophrenic patients from whom P300 event-related potential, smooth eyepursuit eye tracking and verbal fluency were measured within a few days of scanning. Smooth pursuit eye movement abnormality correlated significantly with abnormal tracer uptake in superior pre-frontal cortex on the right and left and inferior pre-frontal cortex on the left. Abnormal eye movement was also associated with higher tracer uptake in left anterior cingulate and left posterior cingulate. P300 latency was significantly correlated with higher tracer uptake in left superior pre-frontal and left parietal regions. Verbal fluency performance was negatively correlated with tracer uptake in left frontal region. Eye tracking abnormality in schizophrenia is associated with bilateral frontallobe disturbance and P300 latency increase with left-sided frontal and temporoparietal dysfunction. There was, however, a significant inverse relation between eye tracking abnormalities and abnormal perfusion in the left anterior cingulate region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:27:02