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Titolo:
LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13
Autore:
WOOSTER R; NEUHAUSEN SL; MANGION J; QUIRK Y; FORD D; COLLINS N; NGUYEN K; SEAL S; TRAN T; AVERILL D; FIELDS P; MARSHALL G; NAROD S; LENOIR GM; LYNCH H; FEUNTEUN J; DEVILEE P; CORNELISSE CJ; MENKO FH; DALY PA; ORMISTON W; MCMANUS R; PYE C; LEWIS CM; CANNONALBRIGHT LA; PETO J; PONDER BAJ; SKOLNICK MH; EASTON DF; GOLDGAR DE; STRATTON MR;
Indirizzi:
INST CANC RES,EPIDEMIOL SECT SUTTON SM2 5NG SURREY ENGLAND INST CANC RES,EPIDEMIOL SECT SUTTON SM2 5NG SURREY ENGLAND INST CANC RES,MOLEC CARCINOGENESIS SECT SUTTON SM2 5NG SURREY ENGLAND MCGILL UNIV,DIV HUMAN GENET MONTREAL H3G 1A4 PQ CANADA MCGILL UNIV,DEPT MED,DIV MED GENET MONTREAL H3G 1A4 PQ CANADA CREIGHTON UNIV,SCH MED,DEPT PREVENT MED & PUBL HLTH OMAHA NE 68178 INT AGCY RES CANC F-69372 LYON 08 FRANCE INST GUSTAVE ROUSSY VILLEJUIF FRANCE LEIDEN UNIV,DEPT PATHOL 2333 AL LEIDEN NETHERLANDS LEIDEN UNIV,DEPT HUMAN GENET 2333 AL LEIDEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT CLIN GENET 1007 MB AMSTERDAM NETHERLANDS UNIV IRELAND TRINITY COLL,ST JAMES HOSP,SCH MED,DEPT MED DUBLIN 8 IRELAND UNIV CAMBRIDGE,DEPT PATHOL,CRC,HUMAN CANC GENET GRP CAMBRIDGE CB2 1QPENGLAND UNIV UTAH,DEPT INTERNAL MED SALT LAKE CITY UT 84132
Titolo Testata:
Science
fascicolo: 5181, volume: 265, anno: 1994,
pagine: 2088 - 2090
SICI:
0036-8075(1994)265:5181<2088:LOABSG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN RECEPTOR GENE; FAMILIAL BREAST; LINKAGE ANALYSIS; ATAXIA-TELANGIECTASIA; OVARIAN-CANCER; P53 GENE; MUTATIONS; HETEROZYGOSITY; CARCINOMA; LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Wooster et al., "LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13", Science, 265(5181), 1994, pp. 2088-2090

Abstract

A small proportion oi breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibilitygenes conferring a high risk of the disease. A genomic linkage searchwas performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized asecond breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:18:42