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Titolo:
A MOUSE MODEL OF HUMAN FAMILIAL ADENOMATOUS POLYPOSIS
Autore:
YANG K; EDELMANN W; FAN KH; LAU K; KOLLI V; FODDE R; KHAN PM; KUCHERLAPATI R; LIPKIN M;
Indirizzi:
ROCKEFELLER UNIV,STRANG CANC RES LAB,BOX 287,1230 YORK AVE NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,STRANG CANC PREVENT CTR NEW YORK NY 10021 ALBERT EINSTEIN COLL MED NEW YORK NY 10461 LEIDEN UNIV LEIDEN NETHERLANDS
Titolo Testata:
The Journal of experimental zoology
fascicolo: 3, volume: 277, anno: 1997,
pagine: 245 - 254
SICI:
0022-104X(1997)277:3<245:AMMOHF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE INTESTINAL NEOPLASIA; APC GENE; COLORECTAL TUMORIGENESIS; ABERRANT CRYPTS; COLON CANCER; MUTATIONS; TUMORS; IDENTIFICATION; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Yang et al., "A MOUSE MODEL OF HUMAN FAMILIAL ADENOMATOUS POLYPOSIS", The Journal of experimental zoology, 277(3), 1997, pp. 245-254

Abstract

In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they includedadenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasiaswere observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 12:55:53