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Titolo:
DIRECT NCA ELECTROPHILIC RADIOIODINATION OF TYROSINE ANALOGS - THEIR IN-VIVO STABILITY AND BRAIN-UPTAKE IN MICE
Autore:
KRUMMEICH C; HOLSCHBACH M; STOCKLIN G;
Indirizzi:
KFA JULICH GMBH,FORSCHUNGSZENTRUM,INST NUKLEARCHEM,POSTFACH 1913 D-52425 JULICH GERMANY KFA JULICH GMBH,FORSCHUNGSZENTRUM,INST NUKLEARCHEM D-52425 JULICH GERMANY
Titolo Testata:
Applied radiation and isotopes
fascicolo: 9, volume: 45, anno: 1994,
pagine: 929 - 935
SICI:
0969-8043(1994)45:9<929:DNEROT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; TUMORS; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Krummeich et al., "DIRECT NCA ELECTROPHILIC RADIOIODINATION OF TYROSINE ANALOGS - THEIR IN-VIVO STABILITY AND BRAIN-UPTAKE IN MICE", Applied radiation and isotopes, 45(9), 1994, pp. 929-935

Abstract

In order to improve tracers for amino acid transport studies with SPET we have radioionated methylated tyrosines and compared their brain uptake and in vivo deiodination in mice. O-methylation not only leads to a higher lipophilicity and hence significantly higher brain uptake with a maximum of 5% dose/g for 3-[I-123]iodo-O-methyl-L-alpha-methyltyrosine (OMIMT) but also significantly prevents in vivo deiodination. High n.c.a. radioiodination yields (greater than or equal to 80%) are obtained for the activated aromatic compounds L-tyrosine and L-alpha-methyltyrosine using Iodo-gen(tm) in a heterogeneous aqueous system. Direct n.c.a. radioiodination of the less-activated O-methyl analogues has been achieved in reasonable yields (60%) with Iodo-gen(tm) in homogeneous TFA solutions containing about 10% of water.

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Documento generato il 21/01/21 alle ore 07:18:37