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Titolo:
THE CLINICAL INTRODUCTION OF GENETIC TESTING FOR ALZHEIMER-DISEASE - AN ETHICAL PERSPECTIVE
Autore:
POST SG; WHITEHOUSE PJ; BINSTOCK RH; BIRD TD; ECKERT SK; FARRER LA; FLECK LM; GAINES AD; JEUNGST ET; KARLINSKY H; MILES S; MURRAY TD; QUAID KA; RELKIN NR; ROSES AD; STGEORGEHYSLOP PH; SACHS GA; STEINBOCK B; TRUSCHKE EF; ZINN AB;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,CTR BIOMED ETH CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT GENET CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT EPIDEMIOL & STAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT ANTHROPOL CLEVELAND OH 44106 UNIV HOSP CLEVELAND,ALZHEIMER CTR CLEVELAND OH 44106 VET AFFAIRS MED CTR,DEPT NEUROL SEATTLE WA 98108 ALZHEIMERS DIS & RELATED DISORDERS ASSOC,CLEVELAND AREA CHAPTER CLEVELAND OH 00000 BOSTON UNIV,SCH MED,DEPT NEUROL BOSTON MA 02118 MICHIGAN STATE UNIV,CTR ETH & HUMANITIES LIFE SCI E LANSING MI 48824 RIVERVIEW HOSP,ALZHEIMERS DIS RES PROGRAM PORT COQUITLAM BC CANADA UNIV MINNESOTA,CTR BIOMED ETH MINNEAPOLIS MN 55455 SUNY ALBANY,COLL HUMANITIES & FINE ARTS,DEPT PHILOSOPHY ALBANY NY 12222 ALZHEIMERS DIS & RELATED DISORDERS ASSOC CHICAGO IL 00000 INDIANA UNIV,MED CTR,DEPT MED & MOL GENET INDIANAPOLIS IN 00000 CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT NEUROL & NEUROSCI NEW YORK NY10021 DUKE UNIV,MED CTR,DEPT NEUROL & NEUROBIOL DURHAM NC 00000 UNIV TORONTO,CTR RES NEURODEGENERAT DIS TORONTO ON CANADA UNIV CHICAGO,MED CTR,DEPT MED CHICAGO IL 60637
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 10, volume: 277, anno: 1997,
pagine: 832 - 836
SICI:
0098-7484(1997)277:10<832:TCIOGT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECURSOR PROTEIN GENE; E TYPE-4 ALLELE; APOLIPOPROTEIN-E; MISSENSE MUTATIONS; HUNTINGTON DISEASE; EPSILON-4 ALLELE; ONSET; RISK; LOCUS; CHROMOSOME-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Post et al., "THE CLINICAL INTRODUCTION OF GENETIC TESTING FOR ALZHEIMER-DISEASE - AN ETHICAL PERSPECTIVE", JAMA, the journal of the American Medical Association, 277(10), 1997, pp. 832-836

Abstract

Objective.-Primary caregivers should be aware of recent progress in the genetics of Alzheimer disease (AD) and of the clinical and ethical considerations raised regarding the introduction of genetic testing for purposes of disease prediction and susceptibility (risk) analysis inasymptomatic individuals and diagnosis in patients who present clinically with dementia, This statement addresses arguments for and againstclinical genetic testing. Participants.-The 20 participants were selected by the investigators (S.G.P., T.H.M., A.B.Z,, and P.J.W.) to achieve balance in the areas of genetics, counseling, ethics, and public policy, and to include leadership from related consensus projects. The consensus group met twice in closed meetings and carried on extensive correspondence over 2 years (1995-1997). The project was supported by the National Human Genome Research Institute of the National Institutes of Health. Evidence.-All 4 involved chromosomes were discussed in group meetings against a background of information from several focus group sessions with AD-affected families. The focus groups comprised volunteers identified by the Cleveland Area Chapter of the Alzheimer's Disease and Related Disorders Association and represented a variety of ethnic populations. Consensus Process.-The first draft was written in April 1996 by the principal investigator (S.G.P.) after the consensus group had met twice. The draft was mailed to all consensus group members 3 times over 6 months for extensive response and redrafting by the principal investigator until all members were satisfied. Conclusions.-Except for autosomal dominant early-onset families, genetic testing in asymptomatic individuals is unwarranted. Use of APOE genetic testing as a diagnostic adjunct in patients already presenting with dementia may prove useful but it remains under investigation. The premature introduction of genetic testing and possible adverse consequences are to beavoided.

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Documento generato il 30/09/20 alle ore 01:19:17