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Titolo:
DETERMINATION OF 1-HYDROXYPYRENE IN RAT URINE USING LIQUID EXTRACTIONAND HPLC UV-DETECTION METHOD
Autore:
LIPNIAK M; GAWLIK M; MADEJ J; NIEZABITOWSKI P;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT TOXICOL PL-30084 KRAKOW POLAND JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL PL-31531 KRAKOW POLAND
Titolo Testata:
Chemia Analityczna
fascicolo: 1, volume: 39, anno: 1994,
pagine: 29 - 32
SICI:
0009-2223(1994)39:1<29:DO1IRU>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYCLIC AROMATIC-HYDROCARBONS; COAL-TAR; EXPOSURE; METABOLITES;
Keywords:
1-HYDROXYPYRENE; POLYCYCLIC AROMATIC HYDROCARBONS; PYRENE; RAT URINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; UV-DETECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M. Lipniak et al., "DETERMINATION OF 1-HYDROXYPYRENE IN RAT URINE USING LIQUID EXTRACTIONAND HPLC UV-DETECTION METHOD", Chemia Analityczna, 39(1), 1994, pp. 29-32

Abstract

Some modifications of HPLC method for identification 1-hydroxypyrene in rat urine are described. As opposed to analytical procedure presented in literature which includes solid phase extraction (SPE) and HPLC determination with fluorescence detection, more approachable extraction with cyclohexane and detection in the UV range were used after enzymic hydrolysis. 1-Hydroxypyrene could be detected in the urine of rats with 88.3 % average recovery level and 0.25 mug l-1 urine detection limit. After pretreatment rats with pyrene p.o. in dose 20 mg kg-1 excretion of 1-hydroxyprene during 72 h increased in urine from 0.22 to 105.7 mug per mg of creatinine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:21:06