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Titolo:
INTEGRIN ALPHA-V-BETA-5 SELECTIVELY PROMOTES ADENOVIRUS-MEDIATED CELL-MEMBRANE PERMEABILIZATION
Autore:
WICKHAM TJ; FILARDO EJ; CHERESH DA; NEMEROW GR;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,10666 N TORREY PINES RD LA JOLLACA 92037 SCRIPPS CLIN & RES INST,DEPT IMMUNOL LA JOLLA CA 92037
Titolo Testata:
The Journal of cell biology
fascicolo: 1, volume: 127, anno: 1994,
pagine: 257 - 264
SICI:
0021-9525(1994)127:1<257:IASPAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOMA CELL; PENTON BASE; HELA-CELLS; RECEPTOR; PROTEIN; ATTACHMENT; VITRONECTIN; TYPE-2; ENTRY; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Wickham et al., "INTEGRIN ALPHA-V-BETA-5 SELECTIVELY PROMOTES ADENOVIRUS-MEDIATED CELL-MEMBRANE PERMEABILIZATION", The Journal of cell biology, 127(1), 1994, pp. 257-264

Abstract

Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5. While both alpha v integrins promote virus internalization, alpha v beta 5 is involved in the subsequent event of membrane permeabilization. Cells transfected with the beta 5 or beta 3 subunit, expressing either alpha v beta 5 and alpha v beta 3, respectively, were capable of supporting Ad2 infection to varying degrees. In this case, cells expressing alpha v beta5 were significantly more susceptible to Ad2-induced membrane permeabilization, as well as to Ad2 infection, than cells expressing alpha v beta 3. Adenovirus-mediated gene delivery was also more efficient in cells expressing alpha v beta 5. These results suggest that the interaction of alpha v beta 5 with Ad2 penton base facilitates the subsequentstep of virus penetration into the cell. These studies provide evidence for the involvement of a cellular receptor in virus-mediated membrane permeabilization and suggest a novel biological role for integrin alpha v beta 5 in the infectious pathway of a human adenovirus.

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Documento generato il 12/08/20 alle ore 20:41:55