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Titolo: LIGAND-SPECIFIC STIMULATION INHIBITION OF CAMP FORMATION BY A NOVEL ENDOTHELIN RECEPTOR SUBTYPE/
Autore: SOKOLOVSKY M; SHRAGALEVINE Z; GALRON R;
- Indirizzi:
- TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL
- Titolo Testata:
- Biochemistry
fascicolo: 38,
volume: 33,
anno: 1994,
pagine: 11417 - 11419
- SICI:
- 0006-2960(1994)33:38<11417:LSIOCF>2.0.ZU;2-F
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ADENYLATE-CYCLASE; CELLS; HYDROLYSIS; HYPERTROPHY; EXPRESSION; PROTEINS; MYOCYTES; GENES;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 21
- Recensione:
- Indirizzi per estratti:
-
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-
- Citazione:
- M. Sokolovsky et al., "LIGAND-SPECIFIC STIMULATION INHIBITION OF CAMP FORMATION BY A NOVEL ENDOTHELIN RECEPTOR SUBTYPE/", Biochemistry, 33(38), 1994, pp. 11417-11419
Abstract
The possible involvement of a cAMP pathway in endothelin (ET) signal transduction was explored using rat atrial slices. We show that ET-1 induces both stimulation and inhibition of cAMP formation, depending onits concentration. Unexpectedly, the effects of ET-3 and of sarafotoxins b and c (SRTX-b and SRTX-c) on this pathway differ from that of ET-1. Moreover, we show that the ET-1-induced formation of cAMP results from catecholamine release in a process mediated by a Ca2+ channel coupled to a pertussis toxin sensitive G-protein. It is concluded that this pathway is mediated by a new ET(A) receptor subtype (probably presynaptic), for which ET-1 is an agonist and ET-3, SRTX-b, and SRTX-c areantagonists.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:54:35