Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ALKYL SUBSTITUTED ANALOGS OF THE FUNCTIONAL M(1) SELECTIVE MUSCARINIC RECEPTOR AGONIST XANOMELINE
Autore:
QUIMBY SJ; SHANNON HE; BYMASTER FP; SAUERBERG P; OLESEN PH; SHEARDOWN MJ; SUZDAK PD; MITCH CH;
Indirizzi:
ELI LILLY & CO,LILLY RES LABS,LILLY CORP CTR INDIANAPOLIS IN 46285 NOVO NORDISK AS,DIV CNS DK-2760 MALOV DENMARK
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 18, volume: 4, anno: 1994,
pagine: 2205 - 2210
SICI:
0960-894X(1994)4:18<2205:SASOAS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-ACYLPYRIDINIUM SALTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Quimby et al., "SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ALKYL SUBSTITUTED ANALOGS OF THE FUNCTIONAL M(1) SELECTIVE MUSCARINIC RECEPTOR AGONIST XANOMELINE", Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2205-2210

Abstract

A series of iadiazol-3-yl)-1,2,5,6-tetrahydrodimethylpyridines have been synthesized and tested in vitro for muscarinic receptor affinity. Methyl substitution at the 5 or 6 position of the tetrahydropyridine resulted in receptor affinities comparable to xanomeline. The use of a sodium borohydride/cerium trichloride reduction was essential for the synthesis of the 3,5-disubstituted tetrahydropyridines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:27:38