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Titolo: ENHANCEMENT OF MOUSE EGG ACTIVATION BY THE KINASE INHIBITOR, 6-DIMETHYLAMINOPURINE (6-DMAP)
Autore: MOSES RM; MASUI Y;
- Indirizzi:
- UNIV TORONTO,DEPT ZOOL TORONTO M5S 1A1 ON CANADA
- Titolo Testata:
- The Journal of experimental zoology
fascicolo: 2,
volume: 270,
anno: 1994,
pagine: 211 - 218
- SICI:
- 0022-104X(1994)270:2<211:EOMEAB>2.0.ZU;2-L
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- CYTOSTATIC FACTOR CSF; METAPHASE-II ARREST; XENOPUS-LAEVIS EGGS; MAP KINASE; CELL-CYCLE; PROTEIN-SYNTHESIS; OOCYTES; INTERPHASE; MATURATION; PHOSPHORYLATION;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 29
- Recensione:
- Indirizzi per estratti:
-
-
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- Citazione:
- R.M. Moses e Y. Masui, "ENHANCEMENT OF MOUSE EGG ACTIVATION BY THE KINASE INHIBITOR, 6-DIMETHYLAMINOPURINE (6-DMAP)", The Journal of experimental zoology, 270(2), 1994, pp. 211-218
Abstract
Metaphase arrest in vertebrate eggs is maintained by the action of cytostatic factor (CSF) on maturation promoting factor (MPF). In amphibian eggs, the kinase inhibitor, 6-dimethylaminopurine (6-DMAP) inactivates both CSF and MPF, resulting in the release from metaphase and entry into interphase. In the mouse, 6-DMAP induces nuclear formation in maturing oocytes, but not in eggs at metaphase II. We found that 6-DMAPaccelerated the transition to interphase in mouse eggs treated with the parthenogenetic agents A23187, cycloheximide, or phorbol 12-myristate 13-acetate (PMA). Newly ovulated eggs, refractory to full activation by A23187, entered interphase when treated with A23187 and 6-DMAP incombination. Occasional batches of eggs formed nuclei in response to 6-DMAP alone. These results are discussed with regard to the possible effects of 6-DMAP on MPF and CSF. (C) 1994 Wiley-Liss, Inc.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:32:32