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Titolo:
ENHANCEMENT OF MOUSE EGG ACTIVATION BY THE KINASE INHIBITOR, 6-DIMETHYLAMINOPURINE (6-DMAP)
Autore:
MOSES RM; MASUI Y;
Indirizzi:
UNIV TORONTO,DEPT ZOOL TORONTO M5S 1A1 ON CANADA
Titolo Testata:
The Journal of experimental zoology
fascicolo: 2, volume: 270, anno: 1994,
pagine: 211 - 218
SICI:
0022-104X(1994)270:2<211:EOMEAB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSTATIC FACTOR CSF; METAPHASE-II ARREST; XENOPUS-LAEVIS EGGS; MAP KINASE; CELL-CYCLE; PROTEIN-SYNTHESIS; OOCYTES; INTERPHASE; MATURATION; PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Moses e Y. Masui, "ENHANCEMENT OF MOUSE EGG ACTIVATION BY THE KINASE INHIBITOR, 6-DIMETHYLAMINOPURINE (6-DMAP)", The Journal of experimental zoology, 270(2), 1994, pp. 211-218

Abstract

Metaphase arrest in vertebrate eggs is maintained by the action of cytostatic factor (CSF) on maturation promoting factor (MPF). In amphibian eggs, the kinase inhibitor, 6-dimethylaminopurine (6-DMAP) inactivates both CSF and MPF, resulting in the release from metaphase and entry into interphase. In the mouse, 6-DMAP induces nuclear formation in maturing oocytes, but not in eggs at metaphase II. We found that 6-DMAPaccelerated the transition to interphase in mouse eggs treated with the parthenogenetic agents A23187, cycloheximide, or phorbol 12-myristate 13-acetate (PMA). Newly ovulated eggs, refractory to full activation by A23187, entered interphase when treated with A23187 and 6-DMAP incombination. Occasional batches of eggs formed nuclei in response to 6-DMAP alone. These results are discussed with regard to the possible effects of 6-DMAP on MPF and CSF. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:32:32