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Titolo:
RISK-FACTORS FOR ADENOCARCINOMAS AND MALIGNANT CARCINOIDS OF THE SMALL-INTESTINE - PRELIMINARY FINDINGS
Autore:
CHEN CC; NEUGUT AI; ROTTERDAM H;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,SCH PUBL HLTH NEW YORK NY 10032
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 3, volume: 3, anno: 1994,
pagine: 205 - 207
SICI:
1055-9965(1994)3:3<205:RFAAMC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROHNS-DISEASE; SMALL-BOWEL; CANCER; TUMORS; COLITIS; BILE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Chen et al., "RISK-FACTORS FOR ADENOCARCINOMAS AND MALIGNANT CARCINOIDS OF THE SMALL-INTESTINE - PRELIMINARY FINDINGS", Cancer epidemiology, biomarkers & prevention, 3(3), 1994, pp. 205-207

Abstract

Although the small intestine contains 75% of the mucosal surface of the gastrointestinal tract, it is the site of only 2% as many malignancies as the large bowel. The association of Crohn's disease with small intestine adenocarcinoma is well known, but the analytic epidemiology of small intestine malignancies has not received much attention. We reviewed the medical records of 19 patients with adenocarcinoma and 17 with malignant carcinoids identified from the Columbia-Presbyterian Medical Center Tumor Registry in the years 1980-1987. These were comparedwith 52 controls with nonmalignant conditions from the same time period. Three adenocarcinoma patients but no carcinoid patients or controls had previous Crohn's disease (P < 0.004). Three adenocarcinomas and three carcinoids, but not controls, had previous cholecystectomy (P < 0.004). Previous peptic ulcer disease was recorded for two patients with adenocarcinoma and three with carcinoid but no controls (P < 0.02, P < 0.0002). The age and sex adjusted odds ratio for cigarette smokingwas 4.6 (95% confidence interval, 1.0-20.7) for adenocarcinomas and 4.2 (0.8-22.4) for carcinoids. The adjusted odds ratio for alcohol consumption was 4.0 (1.0-15.9) for adenocarcinomas and 3.1 (0.7-13.9) for carcinoids. Further studies are warranted to confirm these associations and to identify potential protective factors in the small intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:28:26