Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MONOCYTE CHEMOATTRACTANT PROTEIN-1 MEDIATES MONOCYTE MACROPHAGE INFLUX IN ANTI-THYMOCYTE ANTIBODY-INDUCED GLOMERULONEPHRITIS/
Autore:
WENZEL U; SCHNEIDER A; VALENTE AJ; ABBOUD HE; THAISS F; HELMCHEN UM; STAHL RAK;
Indirizzi:
UNIV HAMBURG,DEPT MED,DIV NEPHROL,PAV 61,MARTINISTR 52 D-20246 HAMBURG GERMANY UNIV HAMBURG,DEPT MED,DIV NEPHROL D-20246 HAMBURG GERMANY UNIV HAMBURG,DEPT PATHOL D-20246 HAMBURG GERMANY UNIV TEXAS,HLTH SCI CTR,DIV NEPHROL SAN ANTONIO TX 00000
Titolo Testata:
Kidney international
fascicolo: 3, volume: 51, anno: 1997,
pagine: 770 - 776
SICI:
0085-2538(1997)51:3<770:MCPMMM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESANGIAL CELL INJURY; CHEMOTACTIC CYTOKINES; SPLEEN-CELLS; EXPRESSION; RAT; MACROPHAGES; RANTES; INFLAMMATION; ADHESION; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
U. Wenzel et al., "MONOCYTE CHEMOATTRACTANT PROTEIN-1 MEDIATES MONOCYTE MACROPHAGE INFLUX IN ANTI-THYMOCYTE ANTIBODY-INDUCED GLOMERULONEPHRITIS/", Kidney international, 51(3), 1997, pp. 770-776

Abstract

Chemokines are a family of chemotactic cytokines whose participation in inflammation in vivo remains to be established. To study the role of monocyte-chemoattractant-protein-1 (MCP-1) on the glomerular accumulation of leukocytes, rats received a neutralizing anti-MCP-1 antiserumfollowing the induction of an glomerulonephritis by an anti-thymocyteantibody (ATS). The infiltration of monocytes/macrophages (M/M) and granulocytes was analyzed by immunohistology. When studied by Northern blotting, glomerular mRNA levels of MCP-1, and interleukin 1 beta (IL-1 beta) increased at three hours and 24 hours following the induction of the injury. The glomerular mRNA expression of intercellular adhesion molecule-1 (ICAM-1) only increased marginally, whereas the expression of the chemokine RANTES was not enhanced. In animals that received anti-MCP-1 antibody glomerular MCP-1 mRNA expression increased. However, the chemoattractant activity for monocytes released into supernatants of isolated glomeruli was reduced. The anti-MCP-1 antibody did not affect glomerular IL-1 beta, ICAM-1 or RANTES mRNA levels. The induction of glomerulonephritis was associated with an increased glomerular recruitment of polymorphonuclear granulocytes (PMNs) at three hours and M/M at 24 hours, when compared with controls. The anti-MCP-1 antiserumsignificantly reduced the glomerular M/M infiltration at 24 hours by 40%, but was without effect on glomerular PMN recruitment or growth ofthe resident glomerular cells. These studies demonstrate that MCP-1 is an important mediator for monocyte recruitment in this model of glomerulonephritis. The reduction of M/M infiltration might affect this glomerular injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:35:58