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Titolo:
DIFFERENTIATION OF POSTPARTUM THYROTOXICOSIS BY SERUM THYROGLOBULIN -USEFULNESS OF A NEW MULTISITE IMMUNORADIOMETRIC ASSAY
Autore:
HIDAKA Y; NISHI I; TAMAKI H; TAKEOKA K; TADA H; MITSUDA N; AMINO N;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT LAB MED,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL SUITA OSAKA 565 JAPAN
Titolo Testata:
Thyroid
fascicolo: 3, volume: 4, anno: 1994,
pagine: 275 - 278
SICI:
1050-7256(1994)4:3<275:DOPTBS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAVES-DISEASE; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Hidaka et al., "DIFFERENTIATION OF POSTPARTUM THYROTOXICOSIS BY SERUM THYROGLOBULIN -USEFULNESS OF A NEW MULTISITE IMMUNORADIOMETRIC ASSAY", Thyroid, 4(3), 1994, pp. 275-278

Abstract

Destruction-induced thyrotoxicosis and Graves' thyrotoxicosis must bedifferentiated, since they are treated differently. To find a useful marker, we examined serial changes in serum thyroglobulin (Tg) concentrations in 20 patients with postpartum thyroid disease (9, euthyroid Hashimoto's disease; 11, Graves' disease in remission in early pregnancy). Serum Tg was measured by a new multisite immunoradiometric assay that allows little influence of anti-Tg autoantibodies. Eight women developed destruction-induced thyrotoxicosis 1 to 4 months postpartum, 6 had relapse of Graves' thyrotoxicosis 2 to 4 months postpartum, and 6 remained euthyroid, In destruction-induced thyrotoxicosis, serum Tg 2 months before the onset was 13.3 +/- 11.4 mu g/L, then clearly increased 1 month before (34.5 +/- 31.9 mu g/L) and was even higher at the onset of thyrotoxicosis (116.5 +/- 137.1 mu g/L). In contrast, serum Tg increased only at the onset in Graves' thyrotoxicosis (from 25.9 +/- 25.2 mu g/L I month before to 76.1 +/- 75.3 mu g/L at the onset,p < 0.05). There was no difference in serum Tg level at the onset between thetwo disorders. However, when data were expressed as the percent increase from the level one month before, and the cut-off value were taken at 150%, all 7 patients above the cut-off developed destruction-induced thyrotoxicosis, and 6 of 7 below had recurrent Graves' thyrotoxicosis. Thus, serial measurement of serum Tg is useful for the differentiation of destruction-induced thyrotoxicosis from Graves' thyrotoxicosis after delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:34:41