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Titolo:
GASTRIC ARTERIOLAR AND VENULAR RESPONSES TO NITROGENOUS AND NONNITROGENOUS VASODILATING AGENTS IN THE RAT
Autore:
CHEN RYZ; CHANG CH; GUTH PH;
Indirizzi:
VET ADM MED CTR W LOS ANGELES,DEPT ANESTHESIOL 212,WILSHIRE & SAWTELLE BLVD LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,SCH MED,ANESTHESIOL SERV LOS ANGELES CA 00000 UNIV CALIF LOS ANGELES,SCH MED,MED & RES SERV LOS ANGELES CA 00000 UNIV CALIF LOS ANGELES,SCH MED,CTR ULCER RES & EDUC LOS ANGELES CA 90024
Titolo Testata:
International journal of microcirculation, clinical and experimental
fascicolo: 4, volume: 14, anno: 1994,
pagine: 197 - 203
SICI:
0167-6865(1994)14:4<197:GAAVRT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROPRUSSIDE-INDUCED HYPOTENSION; SODIUM-NITROPRUSSIDE; NITRIC-OXIDE; BLOOD-FLOW; RELAXING FACTOR; ENDOTHELIAL-CELLS; ANEURYSM SURGERY; NITROGLYCERIN; ADENOSINE; ANESTHESIA;
Keywords:
VASODILATORS; VASODILATION; ARTERIOLES; VENULES; GASTRIC MICROCIRCULATION; IN VIVO MICROSCOPY; NITROGLYCERIN; SODIUM NITROPRUSSIDE; HYDRALAZINE; ADENOSINE; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.Y.Z. Chen et al., "GASTRIC ARTERIOLAR AND VENULAR RESPONSES TO NITROGENOUS AND NONNITROGENOUS VASODILATING AGENTS IN THE RAT", International journal of microcirculation, clinical and experimental, 14(4), 1994, pp. 197-203

Abstract

We made in vivo microvascular observations to simultaneously compare the actions of various direct vasodilators on the resistance and capacitance vessels without confounding systemic hemodynamic effects. The responses of gastric submucosal arteriolar and venular diameters to thetopical application of 10(-7), 10(-5), and 10(-3) M of the vasodilators nitroglycerin (NTG), sodium nitroprusside (SNP), hydralazine (HYD),and adenosine (ADN), and acetylcholine (ACh) were studied in 6 rats for each agent using in vivo microscopy. The basal diameters of arterioles, 37 +/- 2 mu m (mean +/- SE), were maximally dilated to 86 +/- 2 mu m by 10(-3) M ADN, NTG, SNP or ACh, while with 10(-3) M HYD dilationwas just 55%. The basal diameters of venules, 36 +/- 2 mu m, were maximally dilated only to 51 +/- 1 mu m by 10(-3) M ADN, NTG or SNP, while those by 10(-3) M HYD and ACh were 60 and 71%, respectively. We observed that: (1) NTG and SNP were the strongest arteriolar and venular dilators, but at low dose (10(-7) M), NTG was more effective than SNP. (2) Gastric submucosal venules had considerably less dilating capacitythan arterioles. (3) ADN was as effective as NTG and SNP for both arteriolar and venular dilation at 10(-3) M. It was less potent at lower concentrations. (4) ACh was as potent as ADN, NTG and SNP in dilating arterioles, but it was notably less potent in dilating venules. (5) HYD was the weakest arteriolar and venular dilator among all agents studied, and its action on venules was slightly greater than that on arterioles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:52:26