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Titolo:
HUMAN RECOMBINANT EXTRACELLULAR-SUPEROXIDE DISMUTASE TYPE-C IMPROVES CARDIOPLEGIC PROTECTION AGAINST ISCHEMIA REPERFUSION INJURY IN ISOLATED RAT-HEART/
Autore:
PISARENKO OI; STUDNEVA IM; LAKOMKIN VL; TIMOSHIN AA; KAPELKO VI;
Indirizzi:
RUSSIAN ACAD MED SCI,CARDIOL RES CTR,INST EXPTL CARDIOL,3RD CHEREPKOVSKAYA STR 15A MOSCOW 121552 RUSSIA
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 24, anno: 1994,
pagine: 655 - 663
SICI:
0160-2446(1994)24:4<655:HREDTI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICAL GENERATION; OXYGEN FREE-RADICALS; REPERFUSION INJURY; POSTISCHEMIC REPERFUSION; MYOCARDIAL-ISCHEMIA; DAMAGE; MITOCHONDRIA; ARRHYTHMIAS; METABOLISM; RABBIT;
Keywords:
ISOLATED HEART; ISCHEMIA/REPERFUSION INJURY; SUPEROXIDE DISMUTASE; HIGH-ENERGY PHOSPHATES; LACTATE DEHYDROGENASE; OXYGEN RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
O.I. Pisarenko et al., "HUMAN RECOMBINANT EXTRACELLULAR-SUPEROXIDE DISMUTASE TYPE-C IMPROVES CARDIOPLEGIC PROTECTION AGAINST ISCHEMIA REPERFUSION INJURY IN ISOLATED RAT-HEART/", Journal of cardiovascular pharmacology, 24(4), 1994, pp. 655-663

Abstract

The cardioprotective effects of human recombinant extracellular-superoxide dismutase type C (hr-EC-SOD C) were compared with those of bovine Cu,Zn-SOD in isolated working rat heart subjected to 35-min global normothermic ischemia followed by 55-min reperfusion. hr-EC-SOD C or bovine Cu,Zn-SOD (3.10(4) and 6.10(4) IU/L, respectively) was added to St. Thomas' Hospital (STH) cardioplegic solution infused 5 min before and 10 min after the ischemic period. Control hearts were treated with STH cardioplegic solution without SOD. By the end of reperfusion, hr-EC-SOD C-treated hearts recovered left ventricular systolic pressure (LVSP), aortic flow (AF) and cardiac output (CO) to 95 +/- 4, 60 +/- 4, 69 +/- 6% of preischemic value, respectively, as compared with 86 +/- 3, 44 +/- 5, and 52 +/- 6% in the control (p < 0.05). Cardioplegia with hr-EC-SOD C significantly reduced lactate dehydrogenase (LDH) release into myocardial effluent during reperfusion (p < 0.05) and increasedATP, AMP, and total creatine (Cr) tissue contents in reperfused hearts (by 21 +/- 3, 42 +/- 4, and 34 +/- 3%, respectively, as compared with control hearts, p < 0.05). The effects of bovine SOD on functional and biochemical indexes were similar but not statistically significant as compared with control. Treatment with hr-EC-SOD C, but not with bovine SOD, resulted in reduction in hydroxyl radical formation assessed by 5-5-dimethy-1-pyrroline-N-oxide spin trap (DMPO) in coronary effluent at early reperfusion with electron spin resonance (ESR) technique. The results suggest that enhanced myocardial protection against ischemia/reperfusion injury afforded by hr-EC-SOD C is related to scavengingof oxygen-derived free radicals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:53:15