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Titolo:
EFFECTS OF SUBSTANCE-P ON ADRENAL RESPONSES TO ACETYLCHOLINE IN CONSCIOUS CALVES
Autore:
EDWARDS AV; JONES CT;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND UNIV OXFORD,INST MOLEC MED,CELLULAR & DEV PHYSIOL LAB OXFORD OX3 9DS ENGLAND
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 267, anno: 1994,
parte:, 1
pagine: 50000447 - 50000453
SICI:
0002-9513(1994)267:3<50000447:EOSOAR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPLANCHNIC NERVE-STIMULATION; BOVINE CHROMAFFIN CELLS; MUSCARINIC RECEPTORS; NICOTINIC RESPONSE; SYNTHETIC ADRENOCORTICOTROPIN; CATECHOLAMINE SECRETION; MEDULLARY RESPONSES; RAT; DESENSITIZATION; INHIBITION;
Keywords:
ADRENAL MEDULLA; ADRENAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Edwards e C.T. Jones, "EFFECTS OF SUBSTANCE-P ON ADRENAL RESPONSES TO ACETYLCHOLINE IN CONSCIOUS CALVES", The American journal of physiology, 267(3), 1994, pp. 50000447-50000453

Abstract

The effect of intra-aortic infusions of substance P (SP; 10 or 20 pmol.min(-1).kg(-1)) on adrenal responses to acetylcholine (4.5 nmol.min(-1).kg(-1) ia) have been investigated in functionally hypophysectomized calves given exogenous adrenocorticotropic hormone (0.7 pmol.min(-1).kg(-1)). At the lower dose, SP had no effect on cortisol output. In contrast, SP inhibited the output of both catecholamines and enkephalins in response to acetylcholine, without affecting the output of corticotropin-releasing factor (CRF). Increasing the dose of SP to 20 pmol.min(-1).kg(-1) ia significantly reduced the outputs of both cortisol and CRF (P < 0.025 and 0.01 respectively). It is concluded that SP is capable of modulating both adrenal cortical and medullary responses to acetylcholine and that the tatter are more sensitive to this influence than the former.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:24:04