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Titolo:
BONE MASS IMPROVES IN ALCOHOLICS AFTER 2 YEARS OF ABSTINENCE
Autore:
PERIS P; PARES A; GUANABENS N; DELRIO L; PONS F; DEOSABA MJM; MONEGAL A; CABALLERIA J; RODES J; MUNOZGOMEZ J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,SERV REUMATOL,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,METABOL BONE DIS UNIT BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,ALCOHOL UNIT BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,SERV HEPATOL BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,NUCL MED SERV BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,HORMONAL LAB BARCELONA SPAIN CETIR,CTR MED BARCELONA SPAIN
Titolo Testata:
Journal of bone and mineral research
fascicolo: 10, volume: 9, anno: 1994,
pagine: 1607 - 1612
SICI:
0884-0431(1994)9:10<1607:BMIIAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCIRRHOTIC MALE ALCOHOLICS; VITAMIN-D METABOLISM; MINERAL METABOLISM; SERUM OSTEOCALCIN; OSTEOPOROSIS; ETHANOL; DISEASE; MEN; ABUSE; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P. Peris et al., "BONE MASS IMPROVES IN ALCOHOLICS AFTER 2 YEARS OF ABSTINENCE", Journal of bone and mineral research, 9(10), 1994, pp. 1607-1612

Abstract

To evaluate the effect of abstinence on bone mass and bone mineral metabolism in chronic alcoholics, a 2 year longitudinal follow-up study was carried out in a group of 30 chronic alcoholic males who started arehabilitation program. Lumbar and femoral bone mineral density (BMD)and serum levels of osteocalcin and 25-hydroxyvitamin D were measuredat entry and after 1 and 2 years in all patients. Circulating cortisol and parathyroid hormone were measured in 14 and 6 patients, respectively, at entry and every year. Testosterone was measured in 18 patients at entry and after 1 year. At entry, lumbar BMD was significantly lower in alcoholics (1.06 +/- 0.03 g/cm(2)) than in age-matched healthy men (1.22 +/- 0.03 g/cm(2); p < 0.001). Circulating osteocalcin and vitamin D levels were also significantly lower in alcoholics than in controls. Lumbar and femoral neck BMD increased in alcoholics after 2 years of abstinence (lumbar BMD, mean +/- SEM, 1.06 +/- 0,03 to 1.10 +/- 0.03 g/cm(2), p < 0.05; femoral BMD, 0.82 +/- 0.02 to 0.84 +/- 0.02 g/cm(2); p < 0.02). Moreover, lumbar BMD increased in alcoholics (2.9 +/- 1.4%) and decreased in controls (-1.1 +/- 0.2%;p < 0.02). Femoral BMD also increased in alcoholics (2.8 +/- 1,08) but the expected mean decrease of -0.92% was found in healthy age-matched males. Baseline low osteocalcin levels(5.1 +/- 0.6 ng/ml) increased after 1 year (8.6 +/- 0.5 ng/ml, p < 0.001) and 2 years of abstinence (9.5 +/- 0.7 ng/ml, p < 0.001). No significant changes in 25-hydroxgvitamin D, parathyroid hormone, testosterone, or cortisol levels were observed throughout the study. Presence and severity of liver disease did not correlate with bone mass changes. We conclude that in chronic alcoholics lumbar and femoral neck bone mass improves after abstinence. The increase in circulating osteocalcin without associated changes in other circulating hormones further supports the hypothesis that alcohol has deleterious effects on bone formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:30:14