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Titolo:
GENETIC-VARIATION OF FOOT-AND-MOUTH-DISEASE VIRUS DURING PERSISTENT INFECTION IN CATTLE
Autore:
MALIRAT V; DEMELLO PA; TIRABOSCHI B; BECK E; GOMES I; BERGMANN IE;
Indirizzi:
WHO,PAHO,PAN AMER FOOT & MOUTH DIS CTR,POB 589 BR-20001 RIO JANEIRO BRAZIL WHO,PAHO,PAN AMER FOOT & MOUTH DIS CTR BR-20001 RIO JANEIRO BRAZIL UNIV GIESSEN KLINIKUM,INST BIOCHEM W-6300 GIESSEN GERMANY
Titolo Testata:
Virus research
fascicolo: 1, volume: 34, anno: 1994,
pagine: 31 - 48
SICI:
0168-1702(1994)34:1<31:GOFVDP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID SUBSTITUTIONS; ANTIGENIC VARIATION; CELL-CULTURE; MONOCLONAL-ANTIBODIES; SEROTYPE-C; SEQUENCE CHANGES; HETEROGENEITY; VARIANTS; PROTEIN; STRAINS;
Keywords:
FOOT-AND-MOUTH DISEASE VIRUS; PERSISTENCE; GENETIC VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
V. Malirat et al., "GENETIC-VARIATION OF FOOT-AND-MOUTH-DISEASE VIRUS DURING PERSISTENT INFECTION IN CATTLE", Virus research, 34(1), 1994, pp. 31-48

Abstract

Genetic variation of foot-and-mouth disease virus O-1 Campos has beenanalyzed in consecutive isolates recovered over a one- or two-year period from four cattle with experimental persistent infection. Comparisons of RNase T-1 two-dimensional maps and nucleotide sequences of the VP1-coding region revealed a continual, although irregular, increase in the fixation of mutations as the infection progressed. Most changes were not conserved in consecutive isolates. These results, together with the substantial rates of genomic variation observed between some pairs of strains recovered at close time periods, suggested the coexistence of heterogeneous populations in which variants evolve independently from each other, and predominate at irregular time intervals. Furthermore, non-related patterns of variation were observed in the four animals. Similarly, genetic diversity of representative strains from major serotype O outbreaks in endemic disease regions of southeastern Brazil and central eastern Argentina which occurred between 1958 and 1983,suggested that outbreak strains are also likely to represent fluctuations of heterogeneous populations which evolve independently from eachother. The possible role of persistent infections in the introductionof variant populations in the field is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 00:53:50