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Titolo:
1-AMINOCYCLOPROPANE CARBOXYLIC-ACID (ACPC) PREVENTS MU-OPIOID AND DELTA-OPIOID TOLERANCE
Autore:
KOLESNIKOV YA; MACCECHINI ML; PASTERNAK GW;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEURO ONCOL,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEURO ONCOL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT NEUROL & NEUROSCI NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT PHARMACOL NEW YORK NY 10021 SYMPHONY PHARMACEUT MALVERN PA 19355
Titolo Testata:
Life sciences
fascicolo: 18, volume: 55, anno: 1994,
pagine: 1393 - 1398
SICI:
0024-3205(1994)55:18<1393:1C(PMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MORPHINE-TOLERANCE; NMDA RECEPTOR; OPIATE ANALGESIA; ANTAGONIST; GLYCINE; RAT; BLOCKADE; SITE; CHOLECYSTOKININ;
Keywords:
NMDA RECEPTOR; MORPHINE; OPIATE; ENKEPHALIN; NALOXONE BENZOYLHYDRAZONE; U50,488H; GLYCINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y.A. Kolesnikov et al., "1-AMINOCYCLOPROPANE CARBOXYLIC-ACID (ACPC) PREVENTS MU-OPIOID AND DELTA-OPIOID TOLERANCE", Life sciences, 55(18), 1994, pp. 1393-1398

Abstract

1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioidmorphine and the delta ligand [D-Pen(2),D-Pen(5)]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa, opioid U50,488H or the kappa, ligand naloxone benzoylhydrazone (NalBzoH). The actions of ACPC are restricted to tolerance. When given alone, ACPC has no analgesic actions in the tailflick assay and it does not change morphine's ED(50) in naive mice. Chronic administration of ACPC alone for 5 days does not affect the sensitivity of mice to morphine. ACPC also reverses preexisting tolerance. When mice are made tolerant to morphine over 5 days andthen receive ACPC along with their morphine, analgesia returns to naive levels within 3 days despite the continued administration of morphine. The actions of ACPC on opioid tolerance correspond closely with those previously described with both competitive and non-competitive NMDA antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 20:56:40