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Titolo:
ARTERIAL BARORECEPTOR-CARDIAC REFLEX SENSITIVITY IN THE ELDERLY
Autore:
JAMES MA; ROBINSON TG; PANERAI RB; POTTER JF;
Indirizzi:
UNIV LEICESTER,GLENFIELD GEN HOSP,DEPT MED ELDERLY LEICESTER LE3 9QP LEICS ENGLAND UNIV LEICESTER,LEICESTER ROYAL INFIRM,DEPT MED PHYS LEICESTER LEICS ENGLAND
Titolo Testata:
Hypertension
fascicolo: 6, volume: 28, anno: 1996,
pagine: 953 - 960
SICI:
0194-911X(1996)28:6<953:ABRSIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED SYSTOLIC HYPERTENSION; HEART-RATE REFLEX; BLOOD-PRESSURE; BAROREFLEX SENSITIVITY; PLASMA-CATECHOLAMINES; VALSALVA MANEUVER; AGE; RESPONSIVENESS;
Keywords:
PRESSORECEPTORS; BAROREFLEX; AGED PHENYLEPHRINE; NITROPRUSSIDE; VALSALVAS MANEUVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M.A. James et al., "ARTERIAL BARORECEPTOR-CARDIAC REFLEX SENSITIVITY IN THE ELDERLY", Hypertension, 28(6), 1996, pp. 953-960

Abstract

Uncertainty still remains regarding the differing effects of blood pressure and age on baroreceptor-cardiac reflex sensitivity in elderly individuals; these differences are at least partly due to the differingmethods and subject groups used in previous studies. We sought to resolve these issues by examining baroreflex sensitivity in 54 subjects aged 70 +/- 1 years (mean +/- SE; range, 60 to 81) divided into groups with combined systolic diastolic hypertension (CH group, n = 16), isolated systolic hypertension (ISH group, n = 16), or normotension (NT group, n = 22). Baroreflex sensitivity was quantified from the pulse interval and blood pressure responses to the Valsalva maneuver and presser (phenylephrine) and depressor (sodium nitroprusside) stimuli. Baroreflex sensitivity was significantly reduced in the two hypertensive groups but did not differ between them (Valsalva maneuver: CH group, 1.9 /- 0.3 ms/mm Hg; ISH group, 2.8 +/- 0.5; NT group, 4.4 +/- 0.4; phenylephrine: CH group, 3.1 +/- 0.6; ISH group, 3.5 +/- 0.7; NT group, 7.7+/- 1.0; sodium nitroprusside: CH group, 2.1 +/- 0.3; ISH group, 3.6 /- 0.8; NT group, 5.4 +/- 0.3; all P < .05 for comparison with the NTgroup). Thus, this study demonstrated reductions in baroreflex sensitivity with hypertension in elderly subjects consistent across all methods but with no difference between subjects with combined hypertensionand isolated systolic hypertension matched for similar systolic pressure. Baroreflex sensitivity was related only to the level of systolic pressure independent of diastolic pressure or age. If elderly subjectswith isolated systolic hypertension have a greater reduction in large-artery compliance than combined hypertensive subjects with similar systolic pressure, this does not appear to lead to further reductions inbaroreflex sensitivity in these individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 02:33:53