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Titolo:
SALICYLATES FOR ULCERATIVE-COLITIS - THEIR MODE OF ACTION
Autore:
TRAVIS SPL; JEWELL DP;
Indirizzi:
DERRIFORD HOSP,GASTROENTEROL UNIT PLYMOUTH PL6 8DH DEVON ENGLAND RADCLIFFE INFIRM,GASTROENTEROL UNIT OXFORD OX2 6HE ENGLAND
Titolo Testata:
Pharmacology & therapeutics
fascicolo: 2, volume: 63, anno: 1994,
pagine: 135 - 161
SICI:
0163-7258(1994)63:2<135:SFU-TM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; PLATELET-ACTIVATING-FACTOR; ARACHIDONIC-ACID METABOLISM; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; METHIONYL-LEUCYL-PHENYLALANINE; TUMOR-NECROSIS-FACTOR; INTESTINAL EPITHELIAL MONOLAYERS; EQUILIBRIUM INVIVO DIALYSIS; HLA-DR EXPRESSION; 5-AMINOSALICYLIC ACID;
Keywords:
4-AMINOSALICYLIC ACID; 5-AMINOSALICYLIC ACID; CYTOKINES; EICOSANOIDS; OLSALAZINE; REACTIVE OXYGEN METABOLITES; SULFASALAZINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
251
Recensione:
Indirizzi per estratti:
Citazione:
S.P.L. Travis e D.P. Jewell, "SALICYLATES FOR ULCERATIVE-COLITIS - THEIR MODE OF ACTION", Pharmacology & therapeutics, 63(2), 1994, pp. 135-161

Abstract

Delivery of 5-aminosalicylic acid to the colon by sulphasalazine, other ate-bonded compounds and controlled-release preparations is introduced in the context of metabolism by epithelial cells and therapeutic efficacy in ulcerative colitis. Potential modes of action are then reviewed, including actions on luminal bacteria, epithelial cell surface receptors, cellular events (such as nitric oxide release or butyrate oxidation), electrolyte transport and epithelial permeability. Evidence for an influence of salicylates on circulating and lamina propria inflammatory cells is presented, as well as actions on adhesion molecules,chemotactic peptides and inflammatory mediators, such as eicosanoids,platelet-activating factor, cytokines or reactive oxygen metabolites. The precise mechanism will remain uncertain as long as the aetiology of ulcerative colitis is unknown, but a pluripotential mode of action of salicylates is an advantage when influencing the network of events that constitute chronic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:49:48