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Titolo:
TOPOISOMERASE-II-ALPHA EXPRESSION IN ACUTE MYELOID-LEUKEMIA AND ITS RELATIONSHIP TO CLINICAL OUTCOME
Autore:
MCKENNA SL; WEST RR; WHITTAKER JA; PADUA RA; HOLMES JA;
Indirizzi:
UNIV WALES COLL MED,DEPT HAEMATOL,TENOVUS BLDG,HEATH PK CARDIFF CF4 4XN S GLAM WALES UNIV WALES COLL MED,DEPT EPIDEMIOL CARDIFF CF4 4XN S GLAM WALES
Titolo Testata:
Leukemia
fascicolo: 9, volume: 8, anno: 1994,
pagine: 1498 - 1502
SICI:
0887-6924(1994)8:9<1498:TEIAMA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINE; DNA TOPOISOMERASES; DRUG-RESISTANCE; GENE; CDNA; LEUKEMIA; MUTANT; IDENTIFICATION; PROLIFERATION; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Mckenna et al., "TOPOISOMERASE-II-ALPHA EXPRESSION IN ACUTE MYELOID-LEUKEMIA AND ITS RELATIONSHIP TO CLINICAL OUTCOME", Leukemia, 8(9), 1994, pp. 1498-1502

Abstract

The treatment of acute myeloid leukaemia (AML) is often complicated by resistance to chemotherapeutic drugs, Many of the most effective drugs used to treat haematological malignancies target the nuclear enzymetopoisomerase II. Resistance to these drugs in vitro has been associated with quantitative and qualitative changes in the enzyme. In this study, we have investigated topoisomerase II mRNA expression in leukaemic blasts from 23 AML patients. Expression levels ranged from 1-47% relative to the haemopoietic cell line HL60 in 16 evaluable patients. Thirteen of 16 patients achieved complete remission (CR). We have therefore chosen ease of entry into CR as the most sensitive clinical correlate. Decreased topoisomerase II mRNA expression in vitro results in drug resistance. The clinical relevance of reduced expression is not known. All cases of AML and de novo AML have been studied separately, We are unable to identify a correlation between topoisomerase II mRNA levels and ease of entry into CR in either of these groups. Taking these findings into account, group size calculations have been undertaken and indicate that a multi-centre study of this question is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:10:21